National Institute for Health and Welfare, Forensic Toxicology Unit, PO Box 30, FI-00271 Helsinki, Finland.
Finnish Customs Laboratory, PO Box 53, FI-02151 Espoo, Finland.
Forensic Sci Int. 2019 Dec;305:110001. doi: 10.1016/j.forsciint.2019.110001. Epub 2019 Oct 22.
Drug seizures involving a wide variety of emerging new psychoactive substances (NPS) call for new approaches for instant quantification and valuation. Liquid chromatography-chemiluminescence nitrogen detection (LC-CLND) was used in the quantification of opioids with a single secondary standard (caffeine), utilizing the detector's equimolar response to nitrogen. The mean N-equimolarity of CLND for ten fentanyl derivatives and U-47700 by the present LC-CLND method was 96.4% (range 91-101%). The furanylfentanyl samples consisted of 112 powdery samples with a mean (median, range) hydrochloride purity of 13% (4.9%, 0.08-100%). The purity distribution of the furanylfentanyl samples was distinctly bipartite, showing only lower than 9% (N=98) and higher than 60% (N=14) purities. The carfentanil samples consisted of eight brownish sticky samples with a mean (median, range) hydrochloride purity of 0.064% (0.063%, 0.052-0.092%). The U-47700 samples consisted of seven powdery samples with a mean (median, range) hydrochloride purity of 89.0% (100%, 51-100%). The present application to synthetic opioid analysis widens the scope of the established LC-CLND method, previously found useful for single-calibrant quantification of stimulant/hallucinogenic and cannabinoid type of NPS.
涉及各种新兴新型精神活性物质 (NPS) 的药物缉获需要新的方法进行即时定量和估值。液相色谱-化学发光氮检测 (LC-CLND) 用于使用单一二级标准品 (咖啡因) 对阿片类药物进行定量，利用检测器对氮的等摩尔响应。本 LC-CLND 方法对十种芬太尼衍生物和 U-47700 的平均 N-等摩尔性为 96.4%（范围 91-101%）。芬太尼呋喃样本由 112 个粉状样本组成，盐酸盐纯度的平均值（中位数，范围）为 13%（4.9%，0.08-100%）。芬太尼呋喃样本的纯度分布明显呈两部分，仅低于 9%（N=98）和高于 60%（N=14）的纯度。卡芬太尼样本由 8 个棕色粘性样本组成，盐酸盐纯度的平均值（中位数，范围）为 0.064%（0.063%，0.052-0.092%）。U-47700 样本由 7 个粉状样本组成，盐酸盐纯度的平均值（中位数，范围）为 89.0%（100%，51-100%）。本应用于合成阿片类药物分析扩大了已建立的 LC-CLND 方法的范围，该方法先前被发现对兴奋剂/致幻剂和大麻素型 NPS 的单一校准定量有用。
