关于推进化学混合物及其对人类健康和环境风险评估的声明。
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.
机构信息
Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, SE-106 91 Stockholm, Sweden.
Helmholtz Centre for Environmental Research UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
出版信息
Environ Int. 2020 Jan;134:105267. doi: 10.1016/j.envint.2019.105267. Epub 2019 Nov 6.
Abstract
The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, "Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment" was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages.
摘要
目前，人为制造的化学物质、副产品、代谢物和非生物形成的转化产物数量已达数十万种。因此，人类和野生动物会接触到复杂的混合物，而不是一次只接触一种化学物质，也很少只受到一种主导作用的影响。因此，迫切需要制定战略，以评估接触多种有害化学物质及其综合效应的情况。2018 年 5 月，与欧盟资助的研究项目以及委员会服务处和相关欧盟机构一起在 Ispra 的联合研究中心共同组织了一次研讨会，主题为“推进对人类健康和环境中的化学混合物及其风险的评估”。建立这一研究人员和政策制定者的论坛是为了讨论和确定化学混合物风险评估和管理方面的差距，并讨论该领域的最新科学和未来研究需求。基于本次研讨会的介绍和讨论，我们希望提出以下关键信息。
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