遗传血统与前列腺癌差异中 DNA 甲基化变化的关联。
Association of Genetic Ancestry With DNA Methylation Changes in Prostate Cancer Disparity.
机构信息
Department of Family Medicine, Howard University, Washington, DC, U.S.A.
Department of Biochemistry and Molecular Biology Howard University, Washington, DC, U.S.A.
出版信息
Anticancer Res. 2019 Nov;39(11):5861-5866. doi: 10.21873/anticanres.13790.
BACKGROUND
We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity.
MATERIALS AND METHODS
Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively.
RESULTS
Using Spearman rho rank correlation test, the data demonstrated significant (p<0.05) and variable association between African-American ancestry and DNA methylation for all genes investigated in prostate tissues.
CONCLUSION
Genetic ancestry influences DNA methylation and this modifying factor must be considered in epigenetic association studies in populations of admixed patients.
背景
我们假设，由祖先介导的甲基化 DNA 变化可能导致前列腺癌（PCa）中的种族和民族差异。为了验证这一假设，我们分析了遗传祖先与 PCa 差异中 DNA 甲基化变化的关联。
材料与方法
分别使用焦磷酸测序和遗传标记来进行 DNA 甲基化和遗传祖先的检测。
结果
使用 Spearman rho 等级相关检验，数据表明在前列腺组织中，所有被调查的基因中，非裔美国人的祖先与 DNA 甲基化之间存在显著（p<0.05）和可变的关联。
结论
遗传祖先影响 DNA 甲基化，在混合人群的表观遗传关联研究中，必须考虑这种修饰因子。
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