小儿原发性胃肠道非霍奇金淋巴瘤：基于人群的分析。

Primary Pediatric Non-Hodgkin Lymphomas of the Gastrointestinal Tract: A Population-based Analysis.

机构信息

Department of Pediatric Critical Care, Riley Children's hospital, Indiana University, Indianapolis, IN, U.S.A.

Department of Surgery, University of Texas Medical Branch, Galveston, TX, U.S.A.

出版信息

Anticancer Res. 2019 Nov;39(11):6413-6416. doi: 10.21873/anticanres.13855.

DOI:10.21873/anticanres.13855

PMID:31704875

Abstract

BACKGROUND/AIM: The aim of this study was to present the clinical characteristics, natural history and survival outcomes of primary gastrointestinal non-Hodgkin lymphomas (PGINHL) in the pediatric population.

PATIENTS AND METHODS

Surveillance, Epidemiology, and End Results (SEER) database was queried for patients aged 0 to 19 years with PGINHL between 1973 and 2014.

RESULTS

A total of 452 cases were identified [mean age 11.0 (±5.1)] years, whites 84.1%, males (76.5%). The majority of tumors were noted in the small bowel (SB) (47.6%), followed by large bowel (LB) (28.5%) and the stomach (10.0%). Overall, the most common histological subtype was Burkitt lymphoma (51.8%), followed by diffuse large B-cell lymphoma (DLBCL) (26.1%). Mean overall survival (OS) of the entire cohort was 33,33 years with a 5-yr, 10-yr and 30-yr survival rate of 86%, 86% and 79%, respectively. Large bowel tumors had the best long-term survival rates whereas; gastric tumors had the worst with 30-yr survival rate 84% and 74%, respectively. Overall, 328 (72.6%) patients received surgery. No significant survival difference was noted between patients who underwent surgery and those who did not.

CONCLUSION

This study presents the largest dataset of pediatric PGINHL and describes the clinical features and outcomes of these patients in addition to summarizing the literature.

摘要

背景/目的：本研究旨在介绍儿童原发性胃肠道非霍奇金淋巴瘤（PGINHL）的临床特征、自然史和生存结局。

患者和方法

本研究检索了 1973 年至 2014 年间年龄在 0 至 19 岁之间的患有 PGINHL 的患者的监测、流行病学和最终结果（SEER）数据库。

结果

共确定了 452 例病例[平均年龄 11.0（±5.1）岁]，白人占 84.1%，男性占 76.5%。大多数肿瘤位于小肠（SB）（47.6%），其次是大肠（LB）（28.5%）和胃（10.0%）。总体而言，最常见的组织学亚型是伯基特淋巴瘤（51.8%），其次是弥漫性大 B 细胞淋巴瘤（DLBCL）（26.1%）。整个队列的平均总生存期（OS）为 33.33 年，5 年、10 年和 30 年生存率分别为 86%、86%和 79%。大肠肿瘤的长期生存率最好，而胃肿瘤的生存率最差，30 年生存率分别为 84%和 74%。总体而言，328 例（72.6%）患者接受了手术。接受手术和未接受手术的患者之间的生存差异无统计学意义。