在血小板被胶原蛋白激活的过程中，胞质游离钙离子浓度的升高是由血栓素A2直接引发的。
Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen.
作者信息
Moriyama T, Takamura H, Narita H, Tanaka K, Matsuura T, Kito M
机构信息
Research Institute for Food Science, Kyoto University.
出版信息
J Biochem. 1988 Jun;103(6):901-2. doi: 10.1093/oxfordjournals.jbchem.a122383.
The thromboxane A2 antagonist, ONO-3708, completely inhibited the increase in cytosolic free Ca2+ in human platelets during activation with collagen. Half-maximal Ca2+ release and influx required about 3 and 4 nM STA2, a stable thromboxane A2 mimetic, respectively. However, half maximal activation of phospholipase C required about 18 nM STA2. This suggests that thromboxane A2 directly causes Ca2+ mobilization without further activation of phospholipase C during activation of human platelets with collagen.
血栓素A2拮抗剂ONO - 3708能完全抑制胶原激活人血小板过程中胞质游离Ca2+的增加。半最大Ca2+释放和内流分别需要约3 nM和4 nM的STA2（一种稳定的血栓素A2模拟物）。然而，磷脂酶C的半最大激活需要约18 nM的STA2。这表明在用胶原激活人血小板的过程中，血栓素A2直接引起Ca2+动员，而无需进一步激活磷脂酶C。
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