阵发性夜间血红蛋白尿（PNH）中的T淋巴细胞数量与功能：初步报告
T lymphocyte number and functions in paroxysmal nocturnal haemoglobinuria (PNH). A preliminary report.
作者信息
Hernández P, Cruz C, Fernández N L, León R, Ballester J M
出版信息
Haematologia (Budap). 1978;12(1-4):135-9.
T lymphocyte counts in the peripheral blood, lymphocyte response to phytohaemagglutinin (PHA) and delayed hypersensitivity reactions were studied in ten patients with paroxysmal nocturnal haemoglobinuria (PNH). Delayed hypersensitivity was abnormal in most patients and in vitro studies revealed impaired lymphocyte transformation to PHA in 50 per cent of the cases. These tests gave evidence of a functional alteration of lymphocytes in some PNH patients. The hypothesis of a disorder originated in a pluripotent lymphohaematopoietic stem cell is suggested.
对10例阵发性夜间血红蛋白尿（PNH）患者的外周血T淋巴细胞计数、淋巴细胞对植物血凝素（PHA）的反应以及迟发型超敏反应进行了研究。大多数患者的迟发型超敏反应异常，体外研究显示50%的病例淋巴细胞对PHA的转化受损。这些检测结果证明了部分PNH患者淋巴细胞存在功能改变。有人提出该病症起源于多能淋巴造血干细胞紊乱的假说。
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