Suppr超能文献

墙中之砖:发现生物膜细胞外基质的一种新型矿物成分。

A brick in the wall: Discovering a novel mineral component of the biofilm extracellular matrix.

机构信息

Department of Molecular Genetics, Weizmann Institute of Science, 234 Herzl Street, Rehovot, 76100, Israel.

Department of Molecular Genetics, Weizmann Institute of Science, 234 Herzl Street, Rehovot, 76100, Israel.

出版信息

N Biotechnol. 2020 May 25;56:9-15. doi: 10.1016/j.nbt.2019.11.002. Epub 2019 Nov 6.

Abstract

Multicellular bacterial communities, known as biofilms, have been thought to be held together solely by a self-produced organic extracellular matrix (ECM). However, new evidence for a missed mineral constituent of ECM in both Gram-positive and Gram-negative bacterial species, is accumulating. Study of two phylogenetically distinct bacteria, Bacillus subtilis and Mycobacterium smegmatis, identified a novel mechanism crucial for proper biofilm development and architecture - an active, genetically regulated, production of crystalline calcite. The calcite scaffolds stabilize bacterial biofilms, limit penetration of small molecule solutes such as antibiotics and play a conserved role in the assembly of those complex differentiated multicellular communities. This review discusses the recently discovered structural and functional roles of extracellular minerals in biofilms. It is proposed that it is time for a more complete view of the ECM as a complex combination of organic and nonorganic materials, especially in the light of the possible implications for treatment of biofilm infections.

摘要

多细胞细菌群落,称为生物膜,一直被认为仅由自身产生的有机细胞外基质 (ECM) 结合在一起。然而,越来越多的新证据表明,革兰氏阳性和革兰氏阴性细菌物种的 ECM 中存在一种被忽视的矿物质成分。对两种系统发育上不同的细菌枯草芽孢杆菌和耻垢分枝杆菌的研究发现了一种对生物膜正常发育和结构至关重要的新型机制——一种主动的、基因调控的、结晶方解石的产生。方解石支架稳定了细菌生物膜,限制了小分子溶质(如抗生素)的渗透,并在这些复杂的分化多细胞群落的组装中发挥了保守作用。本文综述了最近发现的细胞外矿物质在生物膜中的结构和功能作用。有人提出,现在是时候从更全面的角度看待 ECM 作为有机和无机材料的复杂组合了,特别是考虑到这可能对生物膜感染的治疗产生影响。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验