乳腺癌幸存者及其匹配对照者的长期心理困扰：一项横断面研究。

Long-term psychological distress in breast cancer survivors and their matched controls: A cross-sectional study.

机构信息

University of Groningen, University Medical Center Groningen, Department of General Practice and Elderly Care Medicine, PO Box 196, 9700 AD, Groningen, the Netherlands.

University of Groningen, University Medical Center Groningen, Department of General Practice and Elderly Care Medicine, PO Box 196, 9700 AD, Groningen, the Netherlands; NIVEL, Netherlands Institute of Health Services Research, Utrecht, the Netherlands.

出版信息

Maturitas. 2019 Dec;130:6-12. doi: 10.1016/j.maturitas.2019.09.003. Epub 2019 Sep 16.

DOI:10.1016/j.maturitas.2019.09.003

PMID:31706438

Abstract

INTRODUCTION

Breast cancer survivors often experience psychological distress shortly after diagnosis. Long-term psychological effects, however, have not been clearly demonstrated.

METHODS

This cross-sectional cohort study included 350 breast cancer survivors and 350 age-matched and general-practitioner-matched women. The median follow-up was 10 years. Using logistic regression we compared breast cancer survivors with controls on having (severe) symptoms of depression and/or anxiety, as measured with the Hospital Anxiety and Depression Scale. In multivariable logistic regression, we adjusted the results for a history of depression or prescription of antidepressants.

RESULTS

Larger proportions of breast cancer survivors experienced symptoms of depression (10.6%) compared with controls (4.9%) and symptoms of anxiety (18.6%) compared with controls (16.3%). The odds of symptoms of depression (OR 2.3, 95%CI 1.3-4.2), severe symptoms of depression (OR 3.3, 95%CI 1.1-10.3) and severe symptoms of anxiety (OR 2.1, 95%CI, 1.1-4.0) were significantly higher for breast cancer survivors than for controls, even after adjusting for history of depression or prescription of antidepressants. No significant difference was seen for mild symptoms of anxiety.

CONCLUSIONS

Breast cancer survivors have an increased risk of symptoms of depression, including severe symptoms, and severe symptoms of anxiety compared with controls, for up to at least 10 years after diagnosis.

摘要

简介

乳腺癌幸存者在诊断后不久通常会经历心理困扰。然而，长期的心理影响尚未得到明确证实。

方法

本横断面队列研究纳入了 350 名乳腺癌幸存者和 350 名年龄匹配和普通科医生匹配的女性。中位随访时间为 10 年。我们使用逻辑回归比较了乳腺癌幸存者和对照组在出现（严重）抑郁和/或焦虑症状方面的情况，这些症状是通过医院焦虑和抑郁量表来衡量的。在多变量逻辑回归中，我们根据抑郁史或抗抑郁药处方调整了结果。

结果

与对照组（4.9%）相比，更多的乳腺癌幸存者出现了抑郁症状（10.6%），与对照组（16.3%）相比，出现了焦虑症状（18.6%）。与对照组相比，乳腺癌幸存者出现抑郁症状的可能性更高（OR 2.3，95%CI 1.3-4.2），出现严重抑郁症状的可能性更高（OR 3.3，95%CI 1.1-10.3），出现严重焦虑症状的可能性更高（OR 2.1，95%CI，1.1-4.0），即使在调整了抑郁史或抗抑郁药处方后也是如此。轻度焦虑症状无显著差异。