Wang Yuhong, Yu Lilei, Po Sunny S
Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, No. 9 ZhangZhiDong Street, Wuchang District, Wuhan, Hubei, China.
Department of Medicine, Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Card Electrophysiol Clin. 2019 Dec;11(4):625-634. doi: 10.1016/j.ccep.2019.08.001.
Ventricular tachycardia (VT) remains a common cause of sudden cardiac death. It is widely accepted that VTs are strongly associated with autonomic imbalance with reduced vagal and increased sympathetic activities. Pharmacologic therapy remains the first-line therapy, but antiarrhythmic agents may not be effective or carry significant side effects. Sympathetic denervation is an emerging therapy to prevent or treat VTs by rebalancing the sympathetic and parasympathetic activity. This article focuses on the role of sympathetic activation in VT, and the mapping and ablation of sympathetic nervous system in patients with VT.
室性心动过速(VT)仍然是心源性猝死的常见原因。人们普遍认为,室性心动过速与自主神经失衡密切相关,迷走神经活动减少,交感神经活动增加。药物治疗仍然是一线治疗方法,但抗心律失常药物可能无效或有明显副作用。交感神经去神经支配是一种通过重新平衡交感神经和副交感神经活动来预防或治疗室性心动过速的新兴疗法。本文重点关注交感神经激活在室性心动过速中的作用,以及室性心动过速患者交感神经系统的标测和消融。