颈动脉内膜中层厚度增高诱导的高强度间歇训练可降低 2 型糖尿病患者血清 Dkk-1 和 Sclerostin 水平。
Improved carotid intima-media thickness-induced high-intensity interval training associated with decreased serum levels of Dkk-1 and sclerostin in type 2 diabetes.
机构信息
Department of Exercise Physiology, Faculty of Physical Education and Exercise Sciences, University of Tehran, Tehran, IR, Iran.
Shiraz University of Medical Science, Shiraz, IR, Iran.
出版信息
J Diabetes Complications. 2020 Jan;34(1):107469. doi: 10.1016/j.jdiacomp.2019.107469. Epub 2019 Nov 1.
AIMS
Carotid intima-media thickness (cIMT) is a validated surrogate marker of atherosclerosis. Dickkopf-1 (Dkk-1) and sclerostin modulate wingless signaling, which is involved in atherosclerosis. The purpose of this study was to investigate whether 12 weeks of high-intensity interval training (HIIT) would improve cIMT and serum Dkk-1 and sclerostin levels in patients with type 2 diabetes.
METHODS
Seventy-four sedentary patients with type 2 diabetes were randomly divided into HIIT and control groups. The HIIT group intervention was 6 intervals (4 min) at 85%-90% HR separated by 3 min at 45%-50% HR in 3 sessions/week for 12 weeks. Before and after the intervention, cIMT, artery diameter and wall/lm ratio were recorded with high-resolution ultrasound. Serum sclerostin and Dkk-1 were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS
cIMT decreased significantly in the HIIT group (0.83 ± 0.17 baseline, 0.71 ± 0.14 follow-up) compared to the control group (0.84 ± 0.20 baseline, 0.85 ± 0.19 follow-up) (P < .05). Dkk-1 and sclerostin decreased significantly after 12 weeks of HIIT (P < .01). In addition, VO was increased in the HIIT group than the control group (by 6.2 mL/kg/min) (P < .05). There was a positive correlation between percent changes in cIMT and percent changes in Dkk-1 and sclerostin (both P < .01). Additionally, there were a negative correlation between percent changes VO2peak and cIMT (r = - 0.740, P = .003), Dkk-1 (r = - 0.844, P < .001) and sclerostin (r = - 0.575, P = .001) in HIIT group.
CONCLUSION
Our results indicate that HIIT decreases cIMT, serum levels of Dkk-1 and sclerostin and improves VO in patients with type 2 diabetes.
目的
颈动脉内膜-中层厚度（cIMT）是动脉粥样硬化的有效替代标志物。Dickkopf-1（Dkk-1）和硬化蛋白调节无翅信号，该信号参与动脉粥样硬化。本研究的目的是探讨 12 周高强度间歇训练（HIIT）是否会改善 2 型糖尿病患者的 cIMT 以及血清 Dkk-1 和硬化蛋白水平。
方法
74 名久坐的 2 型糖尿病患者被随机分为 HIIT 和对照组。HIIT 组的干预措施为每周 3 次，每次 6 个间隔（4 分钟），以 85%-90%的 HR 进行，间隔 3 分钟，以 45%-50%的 HR 进行，共 12 周。干预前后，采用高分辨率超声记录 cIMT、动脉直径和壁/内膜比。采用酶联免疫吸附试验（ELISA）测定血清硬化蛋白和 Dkk-1。
结果
与对照组（0.84±0.20 基线，0.85±0.19 随访）相比，HIIT 组的 cIMT 显著降低（0.83±0.17 基线，0.71±0.14 随访）（P<0.05）。HIIT 后 12 周 Dkk-1 和硬化蛋白明显下降（P<0.01）。此外，HIIT 组的 VO 增加量高于对照组（增加了 6.2mL/kg/min）（P<0.05）。cIMT 的变化百分比与 Dkk-1 和硬化蛋白的变化百分比呈正相关（均 P<0.01）。此外，HIIT 组 VO2peak 的变化百分比与 cIMT（r=-0.740，P=0.003）、Dkk-1（r=-0.844，P<0.001）和硬化蛋白（r=-0.575，P=0.001）呈负相关。
结论
我们的结果表明，HIIT 可降低 2 型糖尿病患者的 cIMT、血清 Dkk-1 和硬化蛋白水平，并提高 VO。
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