渐进性自主循环测试中的心率与智利高血压成年人的血管内皮功能障碍结果相关。
Heart Rate from Progressive Volitional Cycling Test Is Associated with Endothelial Dysfunction Outcomes in Hypertensive Chilean Adults.
机构信息
Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile.
Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Los Ángeles 4440000, Chile.
出版信息
Int J Environ Res Public Health. 2023 Feb 27;20(5):4236. doi: 10.3390/ijerph20054236.
BACKGROUND
A progressive volitional cycling test is useful in determining exercise prescription in populations with cardiovascular and metabolic diseases. However, little is known about the association between heart rate during this test and endothelial dysfunction (EDys) parameters in hypertensive (HTN) patients.
OBJECTIVE
To investigate the association between EDys markers (flow-mediated dilation [FMD], pulse wave velocity of the brachial artery [PWVba], and carotid-intima media thickness [cIMT]) and heart rate during a cycling test in HTN adults. A secondary aim was to characterize cardiovascular, anthropometric, and body composition outcomes in this population.
METHODS
This was a descriptive clinical study in which adults (men and women) were assigned to one of three groups: HTN, elevated blood pressure (Ele), or a normotensive control group (CG), and completed a progressive cycling test. The primary outcomes were FMD, PWVba, cIMT, and heart rate (HR) at 25-50 watts (HR), 50-100 watts (HR), and 75-150 watts (HR) of the Astrand test. Secondary outcomes included body mass index (BMI), waist circumference, body fat percentage (BF%), skeletal muscle mass (SMM), resting metabolic rate (RMR), and estimated body age, as measured by a bio-impedance digital scale.
RESULTS
Analyses of the associations between FMD, PWV, and HR, HR, and HR watts revealed no significant association in the HTN, Ele, and CG groups. However, a significant association was found between cIMT and HR watts in the HTN group (R 47.1, β -0.650, = 0.038). There was also a significant trend ( = 0.047) towards increasing PWVba in the CG, Ele, and HTN groups.
CONCLUSION
Heart rate during a progressive cycling test is associated with the EDys parameters cIMT in HTN patients, with particularly strong predictive capacity for vascular parameters in the second and third stages of the Astrand exercise test compared to normotensive control.
背景
渐进式自主循环测试在确定心血管和代谢疾病人群的运动处方方面非常有用。然而，对于高血压（HTN）患者在该测试过程中心率与血管内皮功能障碍（EDys）参数之间的关系知之甚少。
目的
探讨 HTN 成人在循环测试过程中心率与 EDys 标志物（血流介导的舒张功能[FMD]、肱动脉脉搏波速度[PWVba]和颈动脉内膜中层厚度[cIMT]）之间的相关性。次要目的是描述该人群的心血管、人体测量和身体成分结果。
方法
这是一项描述性临床研究，其中成年人（男性和女性）被分配到以下三组之一：HTN、血压升高（Ele）或正常血压对照组（CG），并完成渐进式循环测试。主要结局是 FMD、PWVba、cIMT 和 Astrand 测试中 25-50 瓦（HR）、50-100 瓦（HR）和 75-150 瓦（HR）时的心率（HR）。次要结局包括体重指数（BMI）、腰围、体脂百分比（BF%）、骨骼肌质量（SMM）、静息代谢率（RMR）和通过生物阻抗数字秤测量的估计身体年龄。
结果
在 HTN、Ele 和 CG 组中，FMD、PWV 和 HR、HR 和 HR 瓦之间的关联分析没有发现显著关联。然而，在 HTN 组中发现 cIMT 与 HR 瓦之间存在显著相关性（R 47.1，β-0.650， = 0.038）。CG、Ele 和 HTN 组的 PWVba 也呈显著趋势（ = 0.047）。
结论
渐进式循环测试过程中心率与 HTN 患者的 EDys 参数 cIMT 相关，与正常血压对照组相比，在 Astrand 运动测试的第二和第三阶段，对血管参数具有更强的预测能力。
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