含苦苣菜提取物的自乳化给药系统对链脲佐菌素诱导的糖尿病大鼠的抗炎作用。
Anti-inflammatory effect of self-emulsifying delivery system containing Sonchus oleraceus Linn extract on streptozotocin-induced diabetic rats.
机构信息
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China.
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China.
出版信息
Food Chem Toxicol. 2020 Jan;135:110953. doi: 10.1016/j.fct.2019.110953. Epub 2019 Nov 7.
Edible Sonchus oleraceus Linn is a medicinal plant with many bioactivities such as anti-diabetic activity and anti-inflammatory activity. However, the main bioactive components such as polyphenols in S. oleraceus Linn are poorly absorbed in gastrointestinal tract and rapidly metabolized. Thereby, a self-emulsifying delivery system containing S. oleraceus Linn extracts (SSEDDS) was introduced to evade these problems. Herein, the anti-inflammatory effect of SSEDDS on streptozotocin-induced diabetic rats was investigated. The plasma glucose level was increased and plasma insulin level was decreased in diabetic rats. The levels of NF-κB, TNF-α, and IL-6 in the liver were significantly improved in diabetic rats (p < 0.05). Conversely, daily fed diabetic rats with 100, 200 and 400 mg/kg/day of SSEDS and 1 mg/kg/day metformin for 4 weeks, significantly (p < 0.05) restored all the above mentioned parameters to near normal levels. The immuno-histochemical studies confirmed the anti-inflammatory effects of SSEDDS.
食用菊苣（Edible Sonchus oleraceus Linn）是一种具有多种生物活性的药用植物，如抗糖尿病活性和抗炎活性。然而，菊苣中的主要生物活性成分如多酚在胃肠道中吸收不良且迅速代谢。因此，引入了含有菊苣提取物的自乳化给药系统（SSEDDS）来规避这些问题。本文研究了 SSEDDS 对链脲佐菌素诱导的糖尿病大鼠的抗炎作用。糖尿病大鼠的血糖水平升高，胰岛素水平降低。糖尿病大鼠肝脏中 NF-κB、TNF-α 和 IL-6 的水平显著改善（p<0.05）。相反，连续 4 周每天给糖尿病大鼠喂食 100、200 和 400mg/kg/天的 SSEDS 和 1mg/kg/天的二甲双胍，可显著（p<0.05）将上述所有参数恢复到接近正常水平。免疫组织化学研究证实了 SSEDDS 的抗炎作用。
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