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生物相容性载肉豆蔻油纳米乳剂作为植物驱避剂

Biocompatible Nutmeg Oil-Loaded Nanoemulsion as Phyto-Repellent.

作者信息

Mohd Narawi Masturah, Chiu Hock Ing, Yong Yoke Keong, Mohamad Zain Nur Nadhirah, Ramachandran Muggundha Raoov, Tham Chau Ling, Samsurrijal Siti Fatimah, Lim Vuanghao

机构信息

Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

出版信息

Front Pharmacol. 2020 Mar 17;11:214. doi: 10.3389/fphar.2020.00214. eCollection 2020.

DOI:10.3389/fphar.2020.00214
PMID:32256345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7090166/
Abstract

Plant essential oils are widely used in perfumes and insect repellent products. However, due to the high volatility of the constituents in essential oils, their efficacy as a repellent product is less effective than that of synthetic compounds. Using a nanoemulsion as a carrier is one way to overcome this disadvantage of essential oils. Nutmeg oil-loaded nanoemulsion (NT) was prepared using a high speed homogenizer and sonicator with varying amounts of surfactant, glycerol, and distilled water. Using a phase diagram, different formulations were tested for their droplet size and insect repellent activity. The nanoemulsion containing 6.25% surfactant and 91.25% glycerol (NT 6) had the highest percentage of protection (87.81%) in terms of repellent activity among the formulations tested for the 8 h duration of the experiment. The droplet size of NT 6 was 217.4 nm, and its polydispersity index (PDI) was 0.248. The zeta potential value was -44.2 mV, and the viscosity was 2.49 Pa.s at pH 5.6. The release profile was 71.5%. When the cytotoxicity of NT 6 at 400 μg/mL was tested using the MTS assay, cell viability was 97.38%. Physical appearance and stability of the nanoemulsion improved with the addition of glycerol as a co-solvent. In summary, a nutmeg oil-loaded nanoemulsion was successfully formulated and its controlled release of the essential oil showed mosquito repellent activity, thus eliminating the disadvantages of essential oils.

摘要

植物精油广泛应用于香水和驱虫产品中。然而，由于精油成分的高挥发性，其作为驱虫产品的功效不如合成化合物。使用纳米乳液作为载体是克服精油这一缺点的一种方法。使用高速均质器和超声仪，加入不同量的表面活性剂、甘油和蒸馏水，制备了载肉豆蔻油纳米乳液（NT）。利用相图，测试了不同配方的液滴大小和驱虫活性。在实验持续8小时的测试配方中，含有6.25%表面活性剂和91.25%甘油的纳米乳液（NT 6）在驱虫活性方面具有最高的防护百分比（87.81%）。NT 6的液滴大小为217.4 nm，其多分散指数（PDI）为0.248。ζ电位值为-44.2 mV，在pH 5.6时粘度为2.49 Pa.s。释放率为71.5%。当使用MTS法测试NT 6在400μg/mL时的细胞毒性时，细胞活力为97.38%。加入甘油作为助溶剂后，纳米乳液的物理外观和稳定性得到改善。总之，成功制备了载肉豆蔻油纳米乳液，其对精油的控释显示出驱蚊活性，从而消除了精油的缺点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/13d954c73329/fphar-11-00214-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/67a490d2133c/fphar-11-00214-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/186f9619d907/fphar-11-00214-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/81043bf56e53/fphar-11-00214-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/13d954c73329/fphar-11-00214-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/7ae224bc31b2/fphar-11-00214-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/3d6b8dab4d1c/fphar-11-00214-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/cc06d4310d68/fphar-11-00214-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/b629e652a13d/fphar-11-00214-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/186f9619d907/fphar-11-00214-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb16/7090166/13d954c73329/fphar-11-00214-g010.jpg

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