Department of Internal Medicine, American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon.
Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
J Neonatal Perinatal Med. 2020;13(2):267-273. doi: 10.3233/NPM-190268.
Sustained fetal supraventricular tachycardia (SVT) complicated by hydrops fetalis carries a significant risk of morbidity and mortality. While there is no clear consensus on first- and second-line therapy options for the management of fetal SVT with or without hydrops fetalis, there exists significant nonrandomized experience with a number of antiarrhythmic agents that has founded the basis for management. Furthermore, recently published meta-analyses and ongoing multicenter prospective studies have aimed to bridge the gap in the literature. We report two cases of sustained fetal SVT with severe secondary hydrops fetalis managed successfully with flecainide-sotalol combination therapy in one case and sotalol-digoxin combination therapy in the second and review the literature for the management of fetal SVT.
持续性胎儿室上性心动过速（SVT）并发胎儿水肿会带来显著的发病率和死亡率风险。尽管对于有或没有胎儿水肿的胎儿 SVT 的治疗，一线和二线治疗方案尚无明确共识，但已有大量抗心律失常药物的非随机经验，为治疗奠定了基础。此外，最近发表的荟萃分析和正在进行的多中心前瞻性研究旨在填补文献中的空白。我们报告了两例持续性胎儿 SVT 伴严重继发性胎儿水肿的病例，一例成功地采用氟卡尼-索他洛尔联合治疗，另一例采用索他洛尔-地高辛联合治疗，并对胎儿 SVT 的治疗文献进行了回顾。
