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我们是否应该使用急性肾损伤供者的肾脏进行肾移植?

Should we use kidneys from donors with acute kidney injury for renal transplantation?

机构信息

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China.

出版信息

Nephrology (Carlton). 2020 Feb;25(2):105-115. doi: 10.1111/nep.13679. Epub 2019 Dec 9.

Abstract

The scarcity of donor organs for transplant results in long waiting times for kidney transplantation and low transplant rate worldwide. Utilization of kidneys from donors with acute kidney injury (AKI) is one of the strategies that has attracted attention recently. This article reviewed the outcomes of transplanted renal allografts from donors with acute kidney injury. Key findings about the transplant outcomes included a higher incidence of delayed graft function and primary non function, but respectable outcomes in the context of similar acute rejection rates, and graft function and graft survival. Against this background and with evidence of high mortality for patients remaining on waiting list of transplant, we advocate consideration of AKI donors for kidney transplantation.

摘要

器官捐献的稀缺导致全球范围内进行肾移植的患者需要长时间等待,肾移植率较低。利用急性肾损伤(AKI)供者的肾脏是最近引起关注的策略之一。本文综述了 AKI 供者移植肾的结局。有关移植结局的关键发现包括延迟移植物功能和原发性无功能的发生率较高,但在类似急性排斥率、移植物功能和移植物存活率的背景下,结果是可以接受的。有证据表明,移植等待名单上的患者死亡率较高,在此背景下,我们提倡考虑 AKI 供者进行肾移植。

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