Johnstone T
Translational Research and Animal Clinical Trial Study Group, U-Vet Animal Hospital, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, Australia.
N Z Vet J. 2020 Mar;68(2):69-83. doi: 10.1080/00480169.2019.1689196. Epub 2019 Nov 28.
Multidrug-resistant bacteria are increasingly isolated from the urinary tract of pets, particularly those that suffer from concurrent conditions, have been hospitalised, or were treated with antimicrobials in the recent past. Many of the multidrug-resistant bacteria encountered are resistant to all commonly used oral antibiotics. This poses both a therapeutic dilemma in the individual pet and a threat to public health. This article begins with an overview of multidrug resistance in organisms that are commonly isolated from the urinary tract of pets. This is followed by a proposed clinical approach to managing multidrug-resistant urinary bacteria, which summarises current knowledge regarding appropriate sampling and analysis, reviews the current guidelines regarding appropriate antimicrobial use and discusses treatment options that might be considered. The article highlights several shortcomings of the current knowledge to be considered when planning future clinical research and developing policies.
多重耐药菌越来越多地从宠物的泌尿道中分离出来，尤其是那些患有并发疾病、已住院或近期接受过抗菌药物治疗的宠物。所遇到的许多多重耐药菌对所有常用口服抗生素均耐药。这既给个体宠物带来了治疗难题，也对公共卫生构成了威胁。本文首先概述了常见于宠物泌尿道的生物体中的多重耐药性。接下来是一种针对管理多重耐药性泌尿道细菌的临床方法建议，该方法总结了有关适当采样和分析的现有知识，回顾了有关适当使用抗菌药物的现行指南，并讨论了可能考虑的治疗选择。本文强调了在规划未来临床研究和制定政策时需要考虑的当前知识的几个不足之处。
