Rogers Jeffrey, Middleton Sandy, Wilson Peter H, Johnstone Stuart J
Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia.
Nursing Research Institute, St Vincent's Health Australia and Australian Catholic University, Sydney, NSW, Australia.
Top Stroke Rehabil. 2020 Apr;27(3):161-172. doi: 10.1080/10749357.2019.1673576. Epub 2019 Nov 9.
: Early and objective prediction of functional outcome after stroke is an important issue in rehabilitation. Electroencephalography (EEG) has long been utilized to describe and monitor brain function following neuro-trauma, and technological advances have improved usability in the acute setting. However, skepticism persists whether EEG can provide the same prognostic value as neurological examination.: The current cohort study examined the relationship between acute single-channel EEG and functional outcomes after stroke.: Resting-state EEG recorded at a single left pre-frontal EEG channel (FP1) was obtained from 16 adults within 72 h of first stroke. At 30 and 90 days, measures of disability (modified Rankin Scale; mRS) and involvement in daily activities (modified Barthel Index; mBI) were obtained. Acute EEG measures were correlated with functional outcomes and compared to an early neurological examination of stroke severity using the National Institute of Health Stroke Scale (NIHSS). Classification of outcomes (mRS ≤1 or mBI ≥95) was also examined using Receiver Operator Curve analyses.: One-third to one-half of participants experienced incomplete post-stroke recovery, depending on the time point and measure. Functional outcomes correlated with acute theta values ( 0.45-0.60), with the strength of associations equivalent to previously reported values obtained from conventional multi-channel systems. Acute theta values ≥0.25 were associated with outcomes, with positive (67-83%) and negative predictive values (70-90%) comparable to those obtained using the NIHSS.: Acute, single-channel EEG can provide unique, non-overlapping clinical information, which may facilitate objective prediction of functional outcome after stroke.
卒中后功能结局的早期客观预测是康复领域的一个重要问题。脑电图（EEG）长期以来一直被用于描述和监测神经创伤后的脑功能，并且技术进步提高了其在急性情况下的可用性。然而，对于EEG是否能提供与神经学检查相同的预后价值仍存在疑虑。
本队列研究探讨了急性单通道EEG与卒中后功能结局之间的关系。
从16名首次卒中后72小时内的成年人中获取了在左侧前额叶单通道EEG（FP1）记录的静息态EEG。在30天和90天时，获取了残疾程度测量指标（改良Rankin量表；mRS）和日常活动参与度测量指标（改良Barthel指数；mBI）。将急性EEG测量指标与功能结局进行相关性分析，并与使用美国国立卫生研究院卒中量表（NIHSS）对卒中严重程度进行的早期神经学检查结果进行比较。还使用受试者工作特征曲线分析对结局分类（mRS≤1或mBI≥95）进行了研究。
根据时间点和测量指标，三分之一到二分之一的参与者经历了不完全的卒中后恢复。功能结局与急性θ值相关（0.45 - 0.60），关联强度与先前报道的从传统多通道系统获得的值相当。急性θ值≥0.25与结局相关，其阳性预测值（67 - 83%）和阴性预测值（70 - 90%）与使用NIHSS获得的结果相当。
急性单通道EEG可以提供独特的、不重叠的临床信息，这可能有助于客观预测卒中后的功能结局。
