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急性肾损伤通过半乳糖凝集素-3途径诱导远隔心肌损伤和功能障碍。

Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway.

作者信息

Prud'homme Mathilde, Coutrot Maxime, Michel Thibault, Boutin Louis, Genest Magali, Poirier Françoise, Launay Jean-Marie, Kane Bocar, Kinugasa Satoshi, Prakoura Niki, Vandermeersch Sophie, Cohen-Solal Alain, Delcayre Claude, Samuel Jane-Lise, Mehta Ravindra, Gayat Etienne, Mebazaa Alexandre, Chadjichristos Christos E, Legrand Matthieu

机构信息

INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France.

AP-HP, St-Louis-Lariboisière Hospital, Department of Anesthesiology and Critical Care and Burn Unit, University Paris Diderot, Paris, France.

出版信息

JACC Basic Transl Sci. 2019 Oct 28;4(6):717-732. doi: 10.1016/j.jacbts.2019.06.005. eCollection 2019 Oct.

DOI:10.1016/j.jacbts.2019.06.005
PMID:31709320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6834958/
Abstract

Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.

摘要

急性肾损伤与心力衰竭风险增加及死亡率升高相关。本研究表明，急性肾损伤通过半乳糖凝集素-3（Gal-3）依赖途径诱导远隔心肌功能障碍、损伤及纤维化。Gal-3源自骨髓来源的免疫细胞。阻断该途径可预防心脏损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/f0b09a6a8da4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/911ef51c2a31/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/1dc929f99b43/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/78dfdacc6bb9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/5028b47b9770/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/368304892dfc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/239d9fe90737/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/8bbca1948215/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/f0b09a6a8da4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/911ef51c2a31/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/1dc929f99b43/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/78dfdacc6bb9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/5028b47b9770/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/368304892dfc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/239d9fe90737/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/8bbca1948215/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/6834958/f0b09a6a8da4/gr7.jpg

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