急性肾损伤通过半乳糖凝集素-3途径诱导远隔心肌损伤和功能障碍。

Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway.

作者信息

Prud'homme Mathilde, Coutrot Maxime, Michel Thibault, Boutin Louis, Genest Magali, Poirier Françoise, Launay Jean-Marie, Kane Bocar, Kinugasa Satoshi, Prakoura Niki, Vandermeersch Sophie, Cohen-Solal Alain, Delcayre Claude, Samuel Jane-Lise, Mehta Ravindra, Gayat Etienne, Mebazaa Alexandre, Chadjichristos Christos E, Legrand Matthieu

机构信息

INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France.

AP-HP, St-Louis-Lariboisière Hospital, Department of Anesthesiology and Critical Care and Burn Unit, University Paris Diderot, Paris, France.

出版信息

JACC Basic Transl Sci. 2019 Oct 28;4(6):717-732. doi: 10.1016/j.jacbts.2019.06.005. eCollection 2019 Oct.

Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.