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一例生物瓣二尖瓣功能障碍病例，最初表现为瓣膜血栓形成，随后出现反复血栓形成和心内膜炎。

A Case of Bioprosthetic Mitral Valve Dysfunction, Initially Presenting with Valve Thrombosis Followed by Recurrent Thrombosis and Endocarditis.

作者信息

Apostolidou Eirini, Beale Charles, Poppas Athena, Stockwell Philip, Ehsan Afshin

机构信息

Section of Cardiology and Cardiothoracic Surgery, Rhode Island Hospital, Brown University, Providence, Rhode Island.

出版信息

CASE (Phila). 2019 Jul 3;3(5):210-214. doi: 10.1016/j.case.2019.05.005. eCollection 2019 Oct.

DOI:10.1016/j.case.2019.05.005
PMID:31709372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6833127/
Abstract

• Bioprosthetic valve thrombosis (BPVT) can occur beyond 3 months postimplantation. • BPVT can reoccur after successful treatment with fibrinolysis and anticoagulation. • Other forms of bioprosthetic valve dysfunction can coexist with thrombosis. • Echocardiography can promptly diagnose bioprosthesis thrombosis. • Management requires valve replacement, thrombolysis, or anticoagulation. • After BPVT long-term anticoagulation may be required.

摘要

• 生物瓣血栓形成（BPVT）可在植入后3个月以上发生。

• BPVT在成功进行纤溶和抗凝治疗后可能复发。

• 生物瓣功能障碍的其他形式可与血栓形成并存。

• 超声心动图可迅速诊断生物瓣血栓形成。

• 治疗需要瓣膜置换、溶栓或抗凝。

• BPVT后可能需要长期抗凝。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/28d7f2dba390/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/2f3de5ee0669/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/ad2f8fd1aaf1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/aca5909e8cc1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/50939b48382f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/28d7f2dba390/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/2f3de5ee0669/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/ad2f8fd1aaf1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/aca5909e8cc1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/50939b48382f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/6833127/28d7f2dba390/gr4.jpg

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J Am Coll Cardiol. 2017 May 2;69(17):2193-2211. doi: 10.1016/j.jacc.2017.02.051.
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Prosthetic Heart Valve Thrombosis.人工心脏瓣膜血栓形成。
J Am Coll Cardiol. 2016 Dec 20;68(24):2670-2689. doi: 10.1016/j.jacc.2016.09.958.
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Bioprosthetic Valve Thrombosis Versus Structural Failure: Clinical and Echocardiographic Predictors.生物瓣血栓形成与结构失效：临床和超声心动图预测因素。
J Am Coll Cardiol. 2015 Dec 1;66(21):2285-2294. doi: 10.1016/j.jacc.2015.09.022.
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Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves.生物瓣主动脉瓣叶可能存在亚临床血栓。
N Engl J Med. 2015 Nov 19;373(21):2015-24. doi: 10.1056/NEJMoa1509233. Epub 2015 Oct 5.
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Early stenosis of an aortic porcine bioprosthesis due to thrombosis: Case report and literature review.猪主动脉生物假体因血栓形成导致的早期狭窄：病例报告及文献综述
J Thorac Cardiovasc Surg. 2015 Jun;149(6):e83-6. doi: 10.1016/j.jtcvs.2015.02.039. Epub 2015 Feb 26.
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Misconceptions, diagnostic challenges and treatment opportunities in bioprosthetic valve thrombosis: lessons from a case series.生物瓣血栓形成的误解、诊断挑战及治疗机遇：来自一组病例的经验教训
Eur J Cardiothorac Surg. 2015 Apr;47(4):725-32. doi: 10.1093/ejcts/ezu201. Epub 2014 May 14.
7
2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.2014年美国心脏协会/美国心脏病学会瓣膜性心脏病患者管理指南：美国心脏病学会/美国心脏协会实践指南工作组报告
J Am Coll Cardiol. 2014 Jun 10;63(22):e57-185. doi: 10.1016/j.jacc.2014.02.536. Epub 2014 Mar 3.
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