Carril J M, MacDonald A F, Dendy P P, Keyes W I, Undrill P E, Mallard J R
J Nucl Med. 1979 Nov;20(11):1117-23.
A prospective trial was carried out to assess the contribution made by a radionuclide transverse-section view to conventional radionuclide scans of the brain. Each set of scans was reported by two independent teams of observers, but only one team viewed the tomography section. An abnormality rating was used to decide whether a set of scans was positive or normal. The reports for 512 patients were analyzed and compared with the final independent diagnosis. Greater accuracy of diagnosis with the section view was significant at the 0.1% level; the results showed that failure to detect tumors was almost halved while there was a 16% improvement for the detection of infarcts. Abnormality ratings were also used to plot ROC curves and rating curves; these showed that the addition of the tomographic view increased markedly the proportion of true positives without any increase in the proportion of false-positive reports.
开展了一项前瞻性试验，以评估放射性核素横断面视图对传统脑放射性核素扫描的贡献。每组扫描由两个独立的观察组报告，但只有一组查看断层扫描切片。使用异常评级来确定一组扫描是阳性还是正常。分析了512例患者的报告，并与最终的独立诊断结果进行比较。横断面视图诊断的更高准确性在0.1%水平上具有显著性；结果表明，肿瘤漏检率几乎减半，而梗死灶检测率提高了16%。异常评级还用于绘制ROC曲线和评级曲线；这些曲线表明，增加断层扫描视图显著提高了真阳性比例，而假阳性报告比例没有增加。
