Department of Chemistry, Yunnan Normal University, Kunming, P. R. China.
Electrophoresis. 2020 Jan;41(1-2):104-111. doi: 10.1002/elps.201900294. Epub 2019 Nov 21.
Since some metal-organic cages (MOCs) have been synthesized in past several years, the applications of MOCs such as drug delivery, molecular recognition, separation, catalysis, and gas storage, etc. have been witnessed with a significant increase. However, to the best of our knowledge, so far no one has used MOCs as chiral stationary phase to separate chiral compounds in CEC. In this study, three MOCs were developed as the stationary phase for CEC separation of enantiomers. The MOCs coated capillary column showed good chiral recognition ability for some chiral compounds, including amine, alcohols, ketone, etc. The influence of buffer concentration, applied voltage, pH of buffer solution on the chiral separations was also investigated. The RSDs of run-to-run, day-to-day, and column-to-column for retention time were 2.1-4.67%, 1.2-4.36%, and 3.62-6.43%, respectively. This work reveals that the chiral MOCs material is feasible for the enantioseparation in CEC.
近年来，已经合成了一些金属有机笼（MOC），因此，MOC 的应用如药物输送、分子识别、分离、催化和气体储存等，已经得到了显著的增加。然而，据我们所知，迄今为止，还没有人将 MOC 用作手性固定相来在手性毛细管电泳（CEC）中分离手性化合物。在这项研究中，我们开发了三种 MOC 作为 CEC 分离对映体的固定相。涂覆有 MOC 的毛细管柱对一些手性化合物，包括胺、醇、酮等，表现出良好的手性识别能力。还研究了缓冲液浓度、外加电压、缓冲溶液 pH 值对手性分离的影响。保留时间的运行间、日间和柱间的 RSD 分别为 2.1-4.67%、1.2-4.36%和 3.62-6.43%。这项工作表明，手性 MOC 材料在手性毛细管电泳中的对映体分离是可行的。
