Service de Pharmacie, Hôpitaux Universitaires Paris Ile-de-France Ouest, Site Sainte-Périne, AP-HP, 11 rue Chardon Lagache, Paris, 75016, France.
Service de Médecine Gériatrique, Hôpitaux Universitaires Paris Ile-de-France Ouest, Site Sainte-Périne, AP-HP, 11 rue Chardon Lagache, Paris, 75016, France.
Fundam Clin Pharmacol. 2020 Aug;34(4):521-524. doi: 10.1111/fcp.12520. Epub 2019 Nov 25.
Ceftazidime is a third-generation cephalosporin used for the treatment of Gram-negative bacteria only approved for parenteral use by intravenous and intramuscular route. In some clinical situations, off-label subcutaneous injection could be a salvage route for the administration of antibiotics, especially in geriatrics, despite the paucity of evidence about efficacy and safety. We report a case of a successful and well-tolerated subcutaneous ceftazidime therapy in a 90-year-old woman for the treatment of an acute urinary tract infection caused by Pseudomonas aeruginosa with therapeutic drug monitoring data.
头孢他啶是一种第三代头孢菌素，仅用于治疗革兰氏阴性菌，仅批准通过静脉和肌肉途径进行胃肠外给药。在某些临床情况下，超说明书的皮下注射可能是抗生素给药的一种挽救途径，特别是在老年患者中，尽管关于疗效和安全性的证据很少。我们报告了一例成功且耐受良好的 90 岁女性患者使用头孢他啶皮下治疗由铜绿假单胞菌引起的急性尿路感染的案例，该患者进行了治疗药物监测。
