Minorsky N, Savage D D, Dail W G
Department of Anatomy, University of New Mexico School of Medicine, Albuquerque 87131.
J Auton Nerv Syst. 1988 Jun;23(1):1-8. doi: 10.1016/0165-1838(88)90160-9.
Recent studies have questioned the role of acetylcholine in the physiology of penile erectile tissue. The responsiveness of penile erectile tissue to acetylcholine would depend, in part, on the presence of cholinergic receptors on the smooth muscle. The specific binding of [3H]quinuclidinyl benzilate (QNB) to cholinergic receptors in sections of penile crura of the rat was analyzed by in vitro neurotransmitter autoradiography. Silver grain density measurements indicated that muscarinic cholinergic receptor binding sites are located almost entirely over the corpora cavernosa penis. Virtually no specific [3H]QNB binding was present in the tunica albuginea or adjacent skeletal muscle tissue. Within the erectile tissue, specific binding occurred both over the columns of intrinsic smooth muscle which form the walls of the cavernous spaces and around the more distal branches of the penile arteries. The high concentration of muscarinic cholinergic receptors in the corpora cavernosa penis is consistent with the suggestion that acetylcholine has an important, albeit undefined role in the function of penile erectile tissue.
最近的研究对乙酰胆碱在阴茎勃起组织生理学中的作用提出了质疑。阴茎勃起组织对乙酰胆碱的反应性部分取决于平滑肌上胆碱能受体的存在。通过体外神经递质放射自显影分析了[3H]喹核醇基苯甲酸酯（QNB）与大鼠阴茎脚切片中胆碱能受体的特异性结合。银颗粒密度测量表明，毒蕈碱型胆碱能受体结合位点几乎完全位于阴茎海绵体上。白膜或相邻骨骼肌组织中几乎不存在特异性[3H]QNB结合。在勃起组织内，特异性结合发生在形成海绵体腔壁的固有平滑肌柱上以及阴茎动脉更远端分支周围。阴茎海绵体中毒蕈碱型胆碱能受体的高浓度与乙酰胆碱在阴茎勃起组织功能中具有重要作用（尽管作用尚不明确）的观点一致。
