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阵发性非运动源性运动障碍和半侧肌张力障碍与无症状的乳糜泻相关。

Paroxismal non-kinesigenic dyskinesia and hemidystonia associated with silent celiac disease.

机构信息

Department of Neurology, University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia.

Department of Neurosurgery, University Clinical Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia.

出版信息

Clin Neurol Neurosurg. 2020 Jan;188:105586. doi: 10.1016/j.clineuro.2019.105586. Epub 2019 Nov 4.

Abstract

Paroxismal non-kinesigenic dyskinesia (PNKD) is a rare movement disorder manifesting as choreatic/dystonic movements, usually lasting from minutes to up to 4 h, with perserved consciousness during attacks. Primary PNKD are idiopathic or genetic disorders while secondary PNKD are associated with various neurologic and medical conditions. We present a case with PNKD and right sided hemidystonia in association with celiac disease, responsive to gluten-free diet, not previously reported in available literature. In conclusion, diagnostic tests for celiac disease should be a part of etiological investigations in patients with otherwise unexplained movement disorders including PKND. Gluten free diet could produce a favorable clinical response in those patients.

摘要

阵发性非运动源性运动障碍(PNKD)是一种罕见的运动障碍,表现为舞蹈症/肌张力障碍运动,通常持续数分钟至 4 小时,发作时意识保持清醒。原发性 PNKD 为特发性或遗传性疾病,而继发性 PNKD 与各种神经和医学状况相关。我们报告了一例伴有 PNKD 和右侧半身肌张力障碍的乳糜泻病例,对无麸质饮食有反应,这在现有文献中尚无报道。总之,对于其他原因不明的运动障碍患者,包括 PKND,应将乳糜泻的诊断性检查作为病因学研究的一部分。无麸质饮食可能会使这些患者产生良好的临床反应。

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