Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Mil Med Res. 2019 Nov 13;6(1):34. doi: 10.1186/s40779-019-0223-8.
BACKGROUND: Both periodontal disease and benign prostatic hyperplasia are age-related diseases that affect millions of people worldwide. Hence, this study aimed to investigate the association between periodontal disease and the risk of benign prostatic hyperplasia. METHODS: A total of 4930 participants were selected from an available health examination that was carried out in 2017, only males were considered for further analysis. All eligible males were divided into benign prostatic hyperplasia and normal groups, the benign prostatic hyperplasia group was then divided into prostate volume ≤ 60 g and > 60 g subgroups; all their periodontal status was extracted and then into normal (CPI score of 0), periodontal disease (CPI score between 1 and 4), and periodontitis (CPI score between 3 and 4) groups. The correlation between periodontal disease and benign prostatic hyperplasia was investigated using logistic regression analyses and greedy matching case-control analysis. Subgroup analysis based on prostate volume was also performed. All analyses were conducted with SAS 9.4 software. RESULTS: A total of 2171 males were selected for this analysis. The presence of periodontal disease significantly increased the risk of benign prostatic hyperplasia by 1.68 times (OR = 1.68, 95% CI: 1.26-2.24), and individuals with periodontitis showed a higher risk (OR = 4.18, 95% CI: 2.75-6.35). In addition, among matched cases and controls, this association remained robust (periodontal disease: OR = 1.85, 95% CI: 1.30-2.64; periodontitis: OR = 4.83, 95% CI: 2.57-9.07). Subgroup analysis revealed that periodontal disease significantly increased benign prostate hyperplasia risk as well (for prostate volume ≤ 60 g: OR = 1.64, 95% CI: 1.22-2.20; for volume > 60 g: OR = 2.17, 95% CI: 1.04-4.53), and there was a higher risk in the group with a prostate volume greater than 60 g. CONCLUSION: Periodontal disease is significantly and positively associated with an increased risk of benign prostatic hyperplasia. Further validation studies should be performed to explore the relationship between periodontal treatment and benign prostate hyperplasia.
背景：牙周病和良性前列腺增生都是与年龄相关的疾病，影响着全球数以百万计的人。因此，本研究旨在探讨牙周病与良性前列腺增生风险之间的关系。
方法：从 2017 年进行的一项健康检查中选取了 4930 名参与者，仅考虑男性进行进一步分析。所有符合条件的男性被分为良性前列腺增生组和正常组，良性前列腺增生组又分为前列腺体积≤60g 和>60g 亚组；提取所有参与者的牙周状况，然后分为正常（CPI 评分为 0）、牙周病（CPI 评分为 1 至 4）和牙周炎（CPI 评分为 3 至 4）组。使用逻辑回归分析和贪婪匹配病例对照分析研究牙周病与良性前列腺增生之间的相关性。还根据前列腺体积进行了亚组分析。所有分析均使用 SAS 9.4 软件进行。
结果：共选择了 2171 名男性进行此项分析。患有牙周病会使良性前列腺增生的风险增加 1.68 倍（OR=1.68，95%CI：1.26-2.24），患有牙周炎的风险更高（OR=4.18，95%CI：2.75-6.35）。此外，在匹配的病例和对照中，这种关联仍然很稳健（牙周病：OR=1.85，95%CI：1.30-2.64；牙周炎：OR=4.83，95%CI：2.57-9.07）。亚组分析显示，牙周病也显著增加了良性前列腺增生的风险（对于前列腺体积≤60g：OR=1.64，95%CI：1.22-2.20；对于体积>60g：OR=2.17，95%CI：1.04-4.53），且在前列腺体积大于 60g 的组中风险更高。
结论：牙周病与良性前列腺增生风险显著正相关。应进行进一步的验证研究，以探讨牙周治疗与良性前列腺增生之间的关系。
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