von Dücker Laura, Hüning Svea, Kähler Katharina, Terheyden Patrick, Nashan Do Ro Thée
Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland.
Hautklinik, Klinikum Dortmund, Dortmund, Deutschland.
Hautarzt. 2019 Dec;70(12):975-988. doi: 10.1007/s00105-019-04496-z.
In the context of supportive therapy, possible complaints which may be caused by the cancer itself, by the antitumoral therapy or by psychosocial concerns are considered. Due to the introduction of new anticancer drugs in dermato-oncology, clinicians are confronted with a novel spectrum of adverse events. There are a number of inflammatory, immune-mediated side effects caused by immunotherapies, which can affect virtually any organ. Targeted therapies also have specific side effects. Basically, the management of adverse events depends on their severity. Besides treatment breaks and dosage modifications, immunotherapy-related adverse events are treated with systemic immunosuppressants. Supportive symptomatic therapy is offered. The additional consideration of psychosocial problems can improve quality of life of cancer patients.
在支持性治疗的背景下，会考虑到可能由癌症本身、抗肿瘤治疗或社会心理问题引起的各种不适症状。由于皮肤肿瘤学领域引入了新的抗癌药物，临床医生面临着一系列新的不良事件。免疫疗法会引发许多炎症性、免疫介导的副作用，几乎可影响任何器官。靶向治疗也有特定的副作用。基本上，不良事件的处理取决于其严重程度。除了中断治疗和调整剂量外，免疫疗法相关的不良事件需使用全身性免疫抑制剂进行治疗，并提供支持性对症治疗。对社会心理问题的额外关注可改善癌症患者的生活质量。
