乌干达退伍军人老龄化队列研究指数与HIV相关神经认知障碍无关。
The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda.
作者信息
Awori Violet, Nakigozi Gertrude, Kisakye Alice, Batte James, Anok Aggrey, Mayanja Richard, Nakasujja Noeline, Robertson Kevin R, Gray Ronald H, Wawer Maria J, Sacktor Ned, Saylor Deanna
机构信息
Aga Khan University Hospital, Nairobi, Kenya.
Rakai Health Sciences Program, Kalisizo, Uganda.
出版信息
J Neurovirol. 2020 Apr;26(2):252-256. doi: 10.1007/s13365-019-00806-2. Epub 2019 Nov 12.
The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.
退伍军人老龄化队列研究（VACS）指数在一些人群中与HIV相关神经认知障碍（HAND）有关，但尚未在撒哈拉以南非洲地区进行研究。我们调查了VACS指数在乌干达拉凯农村人口中是否与HAND有关。接受抗逆转录病毒治疗的HIV感染（HIV+）成年人接受了神经认知测试，以使用弗拉斯卡蒂标准确定HAND阶段。记录了所有参与者的VACS成分得分。在156名研究参与者中，HAND阶段为49%正常认知、15%无症状神经认知障碍、31%轻度神经认知障碍和7%HIV相关痴呆。VACS指数与任何HAND阶段之间均无显著关联。在撒哈拉以南非洲地区对VACS指数的首次研究中，我们发现VACS指数得分与HAND之间无关联。
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