异戊二烯基（次膦酰甲基）膦酸酯作为角鲨烯合酶的抑制剂。 - Suppr

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超能文献

Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase.

作者信息

Biller S A, Forster C, Gordon E M, Harrity T, Scott W A, Ciosek C P

机构信息

Squibb Institute for Medical Research, Princeton, New Jersey 08543-4000.

出版信息

J Med Chem. 1988 Oct;31(10):1869-71. doi: 10.1021/jm00118a001.

DOI:10.1021/jm00118a001

PMID:3172121

Abstract

摘要

相似文献

Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase.异戊二烯基（次膦酰甲基）膦酸酯作为角鲨烯合酶的抑制剂。

J Med Chem. 1988 Oct;31(10):1869-71. doi: 10.1021/jm00118a001.

Isoprenyl phosphinylformates: new inhibitors of squalene synthetase.异戊烯基次膦酰甲酸酯：角鲨烯合酶的新型抑制剂。

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J Biol Chem. 1978 Jul 10;253(13):4566-73.

1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.

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Squalene synthetase.角鲨烯合酶

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Different analogues of farnesyl pyrophosphate inhibit squalene synthase and protein:farnesyltransferase to different extents.法尼基焦磷酸的不同类似物对鲨烯合酶和蛋白质：法尼基转移酶的抑制程度不同。

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Stereospecific synthesis and biological evaluation of farnesyl diphosphate isomers.法呢基二磷酸异构体的立体定向合成及生物学评价

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Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase.大鼠肝脏过氧化物酶体中的类异戊二烯生物合成。顺式异戊烯基转移酶和角鲨烯合酶的特性

J Biol Chem. 1992 Sep 15;267(26):18708-14.

Squalene synthase inhibition alters metabolism of nonsterols in rat liver.角鲨烯合酶抑制作用改变大鼠肝脏中非甾体类物质的代谢。

Biochim Biophys Acta. 1996 Oct 18;1303(3):169-79. doi: 10.1016/0005-2760(96)00081-1.

Purification to homogeneity and some properties of squalene synthetase.角鲨烯合成酶的纯化至均一性及其某些性质

Arch Biochem Biophys. 1988 Feb 1;260(2):622-7. doi: 10.1016/0003-9861(88)90490-0.

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Mechanism of action of bisphosphonates.双膦酸盐的作用机制。

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Bisphosphonate mechanism of action.双膦酸盐的作用机制。

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Molecular cloning, in vitro expression and characterization of a plant squalene synthetase cDNA.一种植物鲨烯合酶cDNA的分子克隆、体外表达及特性分析

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Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.人和真菌角鲨烯合酶之间的保守性：结构、功能和调控方面的相似性。

Mol Cell Biol. 1993 May;13(5):2706-17. doi: 10.1128/mcb.13.5.2706-2717.1993.

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.扎拉戈昔酸：一类真菌代谢产物，是角鲨烯合酶的皮摩尔级竞争性抑制剂。

Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):80-4. doi: 10.1073/pnas.90.1.80.

Molecular cloning and characterization of the yeast gene for squalene synthetase.酵母鲨烯合酶基因的分子克隆与特性分析

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