孟加拉玫瑰红对雄性小鼠血清甲状腺激素水平和甲状腺过氧化物酶活性的影响。

Effects of rose bengal on serum levels of thyroid hormones and thyroid peroxidase activity in male mice.

作者信息

Kurebayashi H, Fukuoka M, Nishimaki-Mogami T, Minegishi K, Tanaka A

机构信息

Division of Medical Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan.

出版信息

J Toxicol Sci. 1988 May;13(2):61-70. doi: 10.2131/jts.13.61.

DOI:10.2131/jts.13.61

PMID:3172283

Abstract

The thyrotoxic effect of Rose bengal (RB) (4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; Food Red No. 105) was examined in male (C57BL/6N X C3H/N) F1 mice. They were given drinking-water containing RB at levels of 0 (control), 0.125 and 0.250% for 2 weeks. The effect resulted in decreases in serum levels of 3,5,3'-triiodothyronine (T3) and thyroxine (T4), and slight increases in serum 3,3',5'-triiodothyronine (rT3) levels and thyroid weight, but no difference in the values for the body-weight gain, serum thyroid stimulating hormone (TSH) levels and thyroid peroxidase (TPO) activities. However, the in vitro inhibitory effect of RB on TPO activity was observed by addition of RB to the TPO-catalyzed guaiacol oxidation. These results suggest that RB might have weak goitrogenic properties, inhibiting the peripheral conversion of T4 to T3 and/or inhibiting TPO to lead a decrease of T4 and T3 formation.

摘要

在雄性（C57BL/6N×C3H/N）F1小鼠中检测了孟加拉玫瑰红（RB）（4,5,6,7-四氯-2',4',5',7'-四碘荧光素二钠盐；食用红色素105）的甲状腺毒症作用。给它们饮用含0（对照）、0.125%和0.250% RB的水，持续2周。该作用导致血清3,5,3'-三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平降低，血清3,3',5'-三碘甲状腺原氨酸（rT3）水平和甲状腺重量略有增加，但体重增加值、血清促甲状腺激素（TSH）水平和甲状腺过氧化物酶（TPO）活性无差异。然而，通过向TPO催化的愈创木酚氧化反应中添加RB，观察到RB对TPO活性的体外抑制作用。这些结果表明，RB可能具有较弱的致甲状腺肿特性，抑制T4向T3的外周转化和/或抑制TPO，导致T4和T3生成减少。