Kunos Charles, Ferris Gina, Waggoner Steven
Department of Radiation Oncology, Case Comprehensive Cancer Center and University Hospitals of Cleveland Case Medical Center, Cleveland, OH.
Case Western Reserve University, Cleveland, OH.
Community Oncol. 2010 Oct;7(10):446-450.
In 1999, the National Cancer Institute broadcast a clinical alert promoting the coadministration of radiation therapy and chemotherapy for women with advanced-stage cervical cancer. Since then, patterns of care studies suggest that implementation of these guidelines has been slow. We tested the hypothesis that women with advanced-stage cervical cancer were just as likely to receive coadministration of radiation therapy and chemotherapy at community oncology practices as at hospital-based cancer centers. Between January 2000 and December 2009, 198 women underwent radiation therapy for advanced-stage cervical cancer at treatment centers within a comprehensive cancer center community oncology practice. The majority, 140 (71%), received concurrent radiation therapy and cisplatin chemotherapy. Relative chemotherapy dose, relative time of chemotherapy administration, and relative dose intensity of chemotherapy were similar among the hospital-based comprehensive cancer center and the affiliated community oncology practices. This finding attests to the successful implementation of chemoradiotherapy for cervical cancer in a large networked oncology practice.
1999年，美国国立癌症研究所发布了一项临床警报，提倡对晚期宫颈癌女性患者联合使用放射治疗和化疗。自那时起，医疗模式研究表明这些指南的实施进展缓慢。我们检验了这样一个假设：晚期宫颈癌女性患者在社区肿瘤医疗实践中接受放射治疗与化疗联合使用的可能性与在医院癌症中心相同。在2000年1月至2009年12月期间，198名晚期宫颈癌女性患者在一个综合癌症中心社区肿瘤医疗实践中的治疗中心接受了放射治疗。其中大多数，即140名（71%）患者接受了同步放射治疗和顺铂化疗。在医院综合癌症中心及其附属社区肿瘤医疗实践中，相对化疗剂量、化疗给药相对时间以及化疗相对剂量强度相似。这一发现证明了在大型网络化肿瘤医疗实践中成功实施了宫颈癌的放化疗。
