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The Iron Tale: If It Does Not Kill You, It Makes You Stronger (and Hepcidin Helps).

作者信息

Silvestri Laura

机构信息

Regulation of Iron Metabolism Unit, San Raffaele Scientific Institute, Milan, Italy.

出版信息

Hemasphere. 2018 Feb 14;2(1):e27. doi: 10.1097/HS9.0000000000000027. eCollection 2018 Jan-Feb.

DOI:10.1097/HS9.0000000000000027
PMID:31723756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6745947/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d566/6745947/358741b912e4/hs9-2-e27-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d566/6745947/358741b912e4/hs9-2-e27-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d566/6745947/358741b912e4/hs9-2-e27-g001.jpg

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本文引用的文献

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The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.亲免素FKBP12通过与肝细胞中的骨形态发生蛋白I型受体ALK2结合来抑制铁调素的表达。
Blood. 2017 Nov 9;130(19):2111-2120. doi: 10.1182/blood-2017-04-780692. Epub 2017 Sep 1.
2
Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.莫洛替尼抑制激活素受体1/激活素受体样激酶2,减少铁调素生成,并改善啮齿动物的慢性病贫血。
Blood. 2017 Mar 30;129(13):1823-1830. doi: 10.1182/blood-2016-09-740092. Epub 2017 Feb 10.
3
A Red Carpet for Iron Metabolism.
铁代谢的红地毯
Cell. 2017 Jan 26;168(3):344-361. doi: 10.1016/j.cell.2016.12.034.
4
Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis.小鼠肝脏中的血管分泌型Bmp2信号传导控制正常铁稳态。
Blood. 2017 Jan 26;129(4):415-419. doi: 10.1182/blood-2016-07-729822. Epub 2016 Nov 30.
5
Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.内皮细胞产生小鼠铁稳态所需的骨形态发生蛋白6。
Blood. 2017 Jan 26;129(4):405-414. doi: 10.1182/blood-2016-06-721571. Epub 2016 Nov 18.
6
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.在小鼠中,通过matriptase-2限制肝脏Bmp-Smad信号传导是促红细胞生成素介导的铁调素抑制所必需的。
Blood. 2016 May 12;127(19):2327-36. doi: 10.1182/blood-2015-11-681494. Epub 2016 Jan 11.
7
Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.缺失血红素沉着症相关分子 HFE 和转铁蛋白受体 2 对缺乏骨形态发生蛋白 6 或亚铁整合素的小鼠铁表型的不同影响。
Hepatology. 2016 Jan;63(1):126-37. doi: 10.1002/hep.28254. Epub 2015 Nov 12.
8
Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.在β地中海贫血小鼠模型中,促红细胞生成素铁调素有助于抑制铁调素并导致铁过载。
Blood. 2015 Oct 22;126(17):2031-7. doi: 10.1182/blood-2015-07-658419. Epub 2015 Aug 14.
9
The second transferrin receptor regulates red blood cell production in mice.第二种转铁蛋白受体调节小鼠的红细胞生成。
Blood. 2015 Feb 12;125(7):1170-9. doi: 10.1182/blood-2014-08-596254. Epub 2014 Dec 11.
10
Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo.甘醇分解非抗凝肝素在体外和体内均能抑制铁调素的表达。
Blood. 2014 Mar 6;123(10):1564-73. doi: 10.1182/blood-2013-07-515221. Epub 2014 Jan 7.