Institute of Biochemistry and Molecular Biology, Ulm University, Ulm, Germany.
Wiley Interdiscip Rev Dev Biol. 2020 Jan;9(1):e367. doi: 10.1002/wdev.367. Epub 2019 Nov 14.
Zebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully restoring its size, shape and tissue patterning. Studies over the past decades have identified mechanisms underlying the formation, spatial organization, and regenerative growth of the blastema, a pool of proliferative progenitor cells. The patterning of newly forming tissue is tightly regulated to ensure proper rebuilding of anatomy. Precise niche regulation of retinoic acid and sonic hedgehog signaling ensures adherence to ray-interray boundaries. The molecular underpinnings of systems underlying re-establishment of pre-amputation size and shape (positional information) are also slowly starting to emerge. Osteoblasts play an important role as a cellular source of regenerating skeletal elements, and in zebrafish both osteoblast dedifferentiation as well as de novo osteoblast formation occurs. Both dedifferentiation and proliferation are tightly controlled, which makes it interesting to compare it to tumorigenesis, and to identify potential players involved in these processes. This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration.
斑马鱼具有完全再生失去的附肢的非凡能力，能够忠实地恢复其大小、形状和组织模式。在过去几十年的研究中，已经确定了形成、空间组织和芽基（增殖祖细胞池）再生生长的机制。新形成组织的模式受到严格调节，以确保正确重建解剖结构。视黄酸和 sonic hedgehog 信号的精确生态位调节可确保遵守射线间边界。重新建立截肢前大小和形状（位置信息）的系统的分子基础也开始慢慢显现。成骨细胞作为再生骨骼元素的细胞来源起着重要作用，在斑马鱼中，成骨细胞去分化和新的成骨细胞形成都发生。去分化和增殖都受到严格控制，这使得它与肿瘤发生进行比较并识别参与这些过程的潜在参与者变得很有趣。本文属于以下类别： 成体干细胞、组织更新和再生 > 再生。
