Wustrow T P, Schinko I, Zenner H P
Klinik und Poliklinik für Hals-Nasen-Ohrenkranke, Ludwig-Maximilians-Universität München.
Laryngol Rhinol Otol (Stuttg). 1988 Sep;67(9):469-74.
Despite a twofold recloning, ultrastructural analysis of squamous cell carcinoma lines of the head and neck showed morphologically a very heterogeneous picture in respect of the cytoplasmatic organelles, electron density of the cytoplasma, nucleus and differentiation of the cell membranes. Most prominent were the differences in the content of mitochondria and the formation of intracytoplasmatic filaments and desmosomes. Although the cells have been cultured as single cells, they developed desmosomes in vitro. The cell contact formation varied to such a degree that the plasma membranes of the cells from the tongue squamous cell carcinoma line SCC-25, as an example, were almost completely occupied by desmosomes.
尽管进行了两次再克隆，但对头颈部鳞状细胞癌系的超微结构分析显示，就细胞质细胞器、细胞质、细胞核的电子密度以及细胞膜的分化而言，形态学上呈现出非常异质的景象。最显著的是线粒体含量以及细胞质内细丝和桥粒形成的差异。尽管这些细胞是作为单细胞培养的，但它们在体外形成了桥粒。细胞接触的形成差异很大，例如，来自舌鳞状细胞癌系SCC - 25的细胞的质膜几乎完全被桥粒占据。
