Todd N W, Martin W S
Division of Otolaryngology, Emory University, Atlanta, GA.
Laryngoscope. 1988 Oct;98(10):1046-9. doi: 10.1288/00005537-198810000-00004.
Cystic fibrosis patients commonly have nasal polyps and sinusitis, but surprisingly are spared from an increased occurrence of otitis media. Twenty cystic fibrosis patients whose ages ranged from 13 to 26 years were studied. Only one of these patients had a history of otitis. Minimal temporal bone pneumatization, as determined by computed tomography, was used as an indicator of childhood otitis. The computed tomography had been done as part of the medical evaluation of their symptomatic paranasal sinusitis. On the average, pneumatization volume was larger for the cystic fibrosis patients than for the normal population (p = 0.033, Student's t-test). That is, these data indicate that cystic fibrosis patients had significantly less otitis than the normal population. Assuming that these cystic fibrosis patients are representative, the data may imply that the gene for good musculoskeletal eustachian differentiation is linked with the gene for cystic fibrosis. The data also imply that poor mucociliary transport does not necessarily induce otitis media.
囊性纤维化患者通常会出现鼻息肉和鼻窦炎，但令人惊讶的是，他们中耳感染的发生率并未增加。对20名年龄在13至26岁之间的囊性纤维化患者进行了研究。这些患者中只有一人有中耳炎病史。通过计算机断层扫描确定的颞骨气化程度最低，被用作儿童中耳炎的指标。该计算机断层扫描是作为对其有症状的鼻旁窦炎进行医学评估的一部分进行的。平均而言，囊性纤维化患者的气化体积比正常人群大（p = 0.033，学生t检验）。也就是说，这些数据表明囊性纤维化患者的中耳炎明显少于正常人群。假设这些囊性纤维化患者具有代表性，这些数据可能意味着良好的肌肉骨骼咽鼓管分化基因与囊性纤维化基因相关联。这些数据还意味着黏液纤毛运输不良不一定会诱发中耳炎。
