中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平能否预测肝细胞癌（HCC）患者的死亡率？
May Neutrophil Gelatinase-Associated Lipocalin (NGAL) Level Predict Mortality in Patients with Hepatocellular Carcinoma (HCC)?
机构信息
Department of Internal Medicine, Division of Gastroenterology, Van Education and Research Hospital, Van, Turkey.
Meram School of Medicine, Department of Internal Medicine, Division of Gastroenterology, Necmettin Erbakan University, Meram, Konya, Turkey.
出版信息
J Gastrointest Cancer. 2020 Sep;51(3):932-938. doi: 10.1007/s12029-019-00323-9.
PURPOSE
Hepatocellular carcinoma (HCC) ranks fifth among the common cancers worldwide. Hepatocarcinogenesis is a multiple-phases process, which involves changes in cellular genomes including high cell proliferation.In this study, we aimed to evaluate the relationship of NGAL level at the time of diagnosis with mortality in patients diagnosed with HCC.
MATERIAL AND METHODS
A total of 35 patients who developed HCC on the ground of HBV(+) and 30 healthy subjects were included in the study. Barcelona Clinic Liver Cancer (BCLC), Okuda staging system, and Milan criteria were used for staging of the patients with HCC.
RESULTS
The mean age of all patients was 59.54 ± 11.57 years. Seventeen (48.6%) HCC patients died during 1-year follow-up. Survival of the patients who met the Milan criteria was longer (log-rank (Mantel-Cox) test, χ2 = 5.353, p = 0.021). Kaplan-Meier curve was drawn for NGAL cut-off value, mortality was found to be higher in patients with a NGAL level higher than 217.50 (log-rank (Mantel-Cox) test, χ2 = 15.540, p < 0.001).
CONCLUSION
In this study, we found that high levels of NGAL at the time of diagnosis were associated with poor prognosis in HCC patients.
目的
肝细胞癌（HCC）在全球常见癌症中排名第五。肝癌发生是一个多阶段的过程，涉及包括高细胞增殖在内的细胞基因组变化。在这项研究中，我们旨在评估诊断时 NGAL 水平与 HCC 患者死亡率之间的关系。
材料和方法
共纳入 35 名在乙型肝炎病毒（HBV）阳性基础上发生 HCC 的患者和 30 名健康对照者。巴塞罗那临床肝癌（BCLC）、Okuda 分期系统和米兰标准用于 HCC 患者的分期。
结果
所有患者的平均年龄为 59.54 ± 11.57 岁。17 名（48.6%）HCC 患者在 1 年随访期间死亡。符合米兰标准的患者的生存率更长（对数秩（Mantel-Cox）检验，χ2 = 5.353，p = 0.021）。绘制了 NGAL 截断值的 Kaplan-Meier 曲线，发现 NGAL 水平高于 217.50 的患者死亡率更高（对数秩（Mantel-Cox）检验，χ2 = 15.540，p < 0.001）。
结论
在这项研究中，我们发现诊断时高水平的 NGAL 与 HCC 患者的不良预后相关。
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