School of Chemical and Biomedical Engineering , Nanyang Technological University , 70 Nanyang Drive , 637457 Singapore.
ACS Appl Mater Interfaces. 2020 Feb 5;12(5):5286-5299. doi: 10.1021/acsami.9b15064. Epub 2019 Dec 4.
Cancer theranostics, which combines diagnostic and therapeutic effects into one entity, holds promise in precision medicine. Conventional theranostic agents possess always-on imaging signals and cytotoxic effects and thus often encounter poor selectivity or specificity in cancer treatment. To tackle this issue, activatable phototheranostic materials (PMs) have been developed to simultaneously and specifically turn on their diagnostic signals (fluorescence/self-luminescence/photoacoustic signals) and photothermal/photodynamic effects in response to cancer hallmarks. This Review summarizes the recent progress in the design, synthesis and proof-of-concept applications of activatable PMs. The molecular engineering strategy to increase tumor accumulation and enhance treatment efficacy are highlighted. Current challenges and future perspectives in this emerging field are also discussed.
癌症治疗诊断学，即将诊断和治疗效果结合为一体，在精准医疗中具有广阔的前景。传统的治疗诊断试剂具有持续的成像信号和细胞毒性作用，因此在癌症治疗中常常面临较差的选择性或特异性。为了解决这个问题，已经开发出了可激活的光治疗诊断材料（PMs），以响应癌症标志物，同时特异性地开启它们的诊断信号（荧光/自发光/光声信号）和光热/光动力效应。这篇综述总结了可激活 PMs 的设计、合成和概念验证应用的最新进展。强调了增加肿瘤积累和增强治疗效果的分子工程策略。还讨论了这个新兴领域的当前挑战和未来展望。
