Kabarriti Rafi, Brodin N Patrik, Yaffe Hillary, Barahman Mark, Koba Wade R, Liu Laibin, Asp Patrik, Tomé Wolfgang A, Guha Chandan
Department of Radiation Oncology, Institute for Onco-Physics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY 10461, USA.
Cancers (Basel). 2019 Nov 15;11(11):1796. doi: 10.3390/cancers11111796.
Radiation therapy (RT) has traditionally not been widely used in the management of hepatic malignancies for fear of toxicity in the form of radiation-induced liver disease (RILD). Pre-clinical hepatic irradiation models can provide clinicians with better understanding of the radiation tolerance of the liver, which in turn may lead to the development of more effective cancer treatments. Previous models of hepatic irradiation are limited by either invasive laparotomy procedures, or the need to irradiate the whole or large parts of the liver using external skin markers. In the setting of modern-day radiation oncology, a truly translational animal model would require the ability to deliver RT to specific parts of the liver, through non-invasive image guidance methods. To this end, we developed a targeted hepatic irradiation model on the Small Animal Radiation Research Platform (SARRP) using contrast-enhanced cone-beam computed tomography image guidance. Using this model, we showed evidence of the early development of region-specific RILD through functional single photon emission computed tomography (SPECT) imaging.
传统上，由于担心辐射诱发的肝病（RILD）这种毒性反应，放射治疗（RT）在肝恶性肿瘤的治疗中并未得到广泛应用。临床前肝脏照射模型可以让临床医生更好地了解肝脏的辐射耐受性，这反过来可能会促使开发出更有效的癌症治疗方法。以往的肝脏照射模型存在局限性，要么采用侵入性剖腹手术，要么需要使用外部皮肤标记物对整个肝脏或大部分肝脏进行照射。在现代放射肿瘤学背景下，一个真正具有转化意义的动物模型需要具备通过非侵入性图像引导方法对肝脏特定部位进行放射治疗的能力。为此，我们在小动物辐射研究平台（SARRP）上利用对比增强锥束计算机断层扫描图像引导技术，开发了一种靶向肝脏照射模型。利用该模型，我们通过功能性单光子发射计算机断层扫描（SPECT）成像，证明了区域特异性RILD早期发展的证据。
