Suppr超能文献

孤立性微创二尖瓣手术中的心肌保护方法:胸外科医师协会(STS)数据库结果

Myocardial preservation methods in isolated minimal invasive mitral valve surgery: Society of Thoracic Surgeons (STS) database outcomes.

作者信息

Loberman Dan, Pelletier Marc P, Yazdchi Farchang, Aranki Sary F, Preisler Yoav, Mohr Rephael, Ziv-Baran Tomer

机构信息

Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Cardiovascular Center, Cape Cod Hospital, Hyannis, Massachusetts, USA.

出版信息

J Card Surg. 2020 Jan;35(1):163-173. doi: 10.1111/jocs.14351. Epub 2019 Nov 16.

Abstract

OBJECTIVE

Minimal invasive mitral valve surgery (MIMVS) has become a commonly used approach for mitral valve surgery. Several techniques of myocardial preservation were described in patients undergoing MIMVS. We aim to evaluate preservation technique and short term outcomes.

METHODS

A retrospective analysis of patients who underwent isolated MIMVS and were included in the Society of Thoracic Surgeons (STS) database.

RESULTS

The final cohort included 4976 patients. Mean age was 63.1 years (SD, 12.5) and 42.6% were females. Antegrade delivery method (71.3% of the patients) was the most common, follow by antergrade/retrograde (19.9%). Blood, crystalloid solution, and combination of blood-crystalloid were used in 62.4%, 13.2%, and 13.7%, respectively. In multivariate analysis, cardioplegia technique was associated with mortality (P = .011), pleural effusion (P = .045), and length of ICU stay (P < .001). Antegrade-crystalloid (OR, 3.37; 95%CI, 1.70-6.68) and antegrade/retrograde-blood/crystalloid (OR, 3.28; 95%CI, 1.15-9.38) were associated with increased risk for mortality compared with antegrade-blood cardioplegia. Data on postoperative ejection fraction (EF), CPK-MB, and Troponin was available only in 30%, 9%, and 5% of the patients, respectively, and were not included in the analysis.

CONCLUSIONS

Ante-grade-blood was the most common preservation technique in MIMVS. Ante-grade-crystalloid and ante-grade/retrograde-blood/crystalloid are associated with increased risk for mortality. The results suggest that using crystalloid solutions for cardioplegia should be carefully considered. The STS database as a source for MIMVS outcome analysis is lacking, both in detailed specification of different surgical technique aspects, and in actual data collection of already existing categories.

摘要

目的

微创二尖瓣手术(MIMVS)已成为二尖瓣手术常用的方法。在接受MIMVS的患者中描述了几种心肌保护技术。我们旨在评估保护技术和短期结果。

方法

对接受单纯MIMVS并纳入胸外科医师协会(STS)数据库的患者进行回顾性分析。

结果

最终队列包括4976例患者。平均年龄为63.1岁(标准差12.5),女性占42.6%。顺行给药法(71.3%的患者)最常见,其次是顺行/逆行给药法(19.9%)。分别有62.4%、13.2%和13.7%的患者使用血液、晶体溶液以及血液-晶体溶液联合使用。多因素分析显示,心脏停搏技术与死亡率(P = 0.011)、胸腔积液(P = 0.045)和重症监护病房住院时间(P < 0.001)相关。与顺行血液心脏停搏相比,顺行晶体溶液(比值比,3.37;95%可信区间,1.70 - 6.68)和顺行/逆行血液/晶体溶液(比值比,3.28;95%可信区间,1.15 - 9.38)与死亡风险增加相关。术后射血分数(EF)、肌酸磷酸激酶同工酶(CPK-MB)和肌钙蛋白的数据分别仅在30%、9%和5%的患者中可获得,未纳入分析。

结论

顺行血液是MIMVS中最常见的保护技术。顺行晶体溶液和顺行/逆行血液/晶体溶液与死亡风险增加相关。结果表明,应谨慎考虑使用晶体溶液进行心脏停搏。STS数据库作为MIMVS结果分析的来源,在不同手术技术方面的详细规范以及现有类别实际数据收集方面都存在不足。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验