Department of Internal Medicine, Division of Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.
Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
Adv Chronic Kidney Dis. 2019 Sep;26(5):360-368. doi: 10.1053/j.ackd.2019.08.015.
The kidney biopsy advanced our understanding of kidney disease in systemic lupus erythematosus. It allowed for better recognition and classification of lupus nephritis (LN). Several LN classifications have been devised in an effort to inform treatment decision and predict prognosis, and these are being further updated. In this review, we will examine the role of diagnostic as well as repeat kidney biopsy in the management of LN, including the potential role of molecular interrogation as a step forward beyond conventional histology to guide the discovery of novel biomarkers and a precision medicine approach to the management of LN.
肾脏活检促进了我们对系统性红斑狼疮中肾脏疾病的认识。它有助于更好地识别和分类狼疮性肾炎（LN）。已经设计了几种 LN 分类方法，以提供治疗决策和预测预后的依据，并且这些方法正在进一步更新。在这篇综述中，我们将研究诊断性和重复肾脏活检在 LN 管理中的作用，包括分子检测作为超越传统组织学的一步，以指导发现新的生物标志物和 LN 管理的精准医学方法的潜在作用。
