Marron Robert M, Vega Sanchez Maria Elena, Clauss Heather, Mamary A James
Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Transplant Proc. 2019 Dec;51(10):3391-3394. doi: 10.1016/j.transproceed.2019.07.017. Epub 2019 Nov 14.
Our case series describes three patients who have received single-lung transplantations for idiopathic pulmonary fibrosis (IPF) that develop cytomegalovirus (CMV) disease and hypoxemic respiratory failure with radiographic opacification of the native lung and sparing of the allograft.
Hypoxemia resolved with treatment and with resolution of CMV viremia. Viral infections causing IPF exacerbations have been described in the literature, however, pulmonary CMV disease in single-lung transplant recipients has typically been observed as pneumonitis of the allograft.
These clinical scenarios are consistent with acute exacerbation of native-lung IPF and subradiographic pneumonitis of the allograft caused by CMV disease.
我们的病例系列描述了三名因特发性肺纤维化（IPF）接受单肺移植的患者，他们出现了巨细胞病毒（CMV）疾病和低氧性呼吸衰竭，影像学显示自体肺出现混浊，而异体肺未受累。
低氧血症通过治疗及CMV病毒血症的消退而得到缓解。文献中已描述了导致IPF加重的病毒感染，然而，单肺移植受者的肺部CMV疾病通常表现为异体肺的肺炎。
这些临床情况与自体肺IPF的急性加重以及由CMV疾病引起的异体肺亚影像学肺炎相符。
