Gil F, Elvas L, Raposo S, Carvalho T, Gil J, Cardoso J C, Fernandes B
Department of Dermatology, Hospital de Santarém EPE, Santarém.
Dermatol Online J. 2019 Oct 15;25(10):13030/qt9xx6p2tt.
Cutaneous metastases are rarely the initial manifestation of a previously undiagnosed malignancy and keratoacanthoma-like lesions are a notoriously unusual presentation pattern of cutaneous dissemination of a primary tumor. Herein, we report a 40-year-old woman presenting to our dermatology department with multiple keratoacanthoma-like scalp nodules. Subsequent investigation determined it to be the first manifestation of a disseminated endometrial epithelioid trophoblastic tumor, eventually causing the patient's death. Epithelioid trophoblastic tumor, a rare form of gestational trophoblastic disease, is a recently described neoplasm whose cutaneous metastasis has not been previously reported in the literature.
皮肤转移瘤很少是先前未诊断出的恶性肿瘤的初始表现，而角化棘皮瘤样病变是原发性肿瘤皮肤播散的一种极其罕见的表现形式。在此，我们报告一名40岁女性，因头皮出现多个角化棘皮瘤样结节前来皮肤科就诊。后续检查确定这是一例弥漫性子宫内膜上皮样滋养细胞肿瘤的首发表现，最终导致患者死亡。上皮样滋养细胞肿瘤是妊娠滋养细胞疾病的一种罕见形式，是一种最近才被描述的肿瘤，其皮肤转移此前在文献中尚未见报道。
