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社交认知中的组合催产素神经药理学。

Combinatorial Oxytocin Neuropharmacology in Social Cognition.

机构信息

Department of Psychology, Yale University, New Haven, CT, USA.

Department of Psychology, Yale University, New Haven, CT, USA; Department of Psychology, University of Turin, Torino, Italy.

出版信息

Trends Cogn Sci. 2020 Jan;24(1):8-12. doi: 10.1016/j.tics.2019.10.004. Epub 2019 Nov 14.

DOI:10.1016/j.tics.2019.10.004
PMID:31735541
Abstract

The efficacy and reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undependable. We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior. We further suggest that combinatorial neuropharmacology approaches should exploit the interactions between OT and serotonin to regulate social functions.

摘要

经鼻给予催产素(OT)以临床增强社会功能的疗效和可靠性尚不可靠。我们讨论了同时给予 OT 和纳洛酮(NAL)以有力调节社会行为的潜在益处。我们进一步建议,组合神经药理学方法应利用 OT 和 5-羟色胺之间的相互作用来调节社会功能。

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Combinatorial approaches for treating neuropsychiatric social impairment.联合治疗神经精神社会功能障碍。
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Interplay between the oxytocin and opioid systems in regulating social behaviour.催产素和阿片系统在调节社会行为中的相互作用。
Philos Trans R Soc Lond B Biol Sci. 2022 Aug 29;377(1858):20210050. doi: 10.1098/rstb.2021.0050. Epub 2022 Jul 11.
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Intranasal Oxytocin for Stimulant Use Disorder Among Male Veterans Enrolled in an Opioid Treatment Program: A Randomized Controlled Trial.鼻内注射催产素治疗参加阿片类药物治疗项目的男性退伍军人的兴奋剂使用障碍:一项随机对照试验。
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