Nigmatullin N R, Snetkov V A, Nikol'skiĭ E E, Magazanik L G
Neirofiziologiia. 1988;20(3):390-8.
The numerical model of the miniature end-plate current MEPC described earlier was systematically analyzed to obtain an optimal set of parameters. This set permits simulating a number of experimental effects: time course of normal MEPC, cholinesterase inhibition, alpha-bungarotoxin action, potential dependence of MEPC, etc. The time course of the simulated "giant" MEPC fitted the experimental data only partially. A good correspondence between the model and experimental data underlies the conclusion that this model reflects well the relative contribution of several processes to MEPC generation.
对之前描述的微型终板电流(MEPC)数值模型进行了系统分析,以获得一组最优参数。这组参数能够模拟多种实验效应:正常MEPC的时间进程、胆碱酯酶抑制、α-银环蛇毒素作用、MEPC的电位依赖性等。模拟的“巨型”MEPC的时间进程仅部分拟合了实验数据。该模型与实验数据之间的良好对应关系为以下结论提供了依据:此模型很好地反映了多个过程对MEPC产生的相对贡献。