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1
The correlations of tumor mutational burden among single-region tissue, multi-region tissues and blood in non-small cell lung cancer.非小细胞肺癌中单区域组织、多区域组织和血液肿瘤突变负荷的相关性。
J Immunother Cancer. 2019 Apr 3;7(1):98. doi: 10.1186/s40425-019-0581-5.
2
Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray.程序性细胞死亡配体 1 免疫组织化学：手术标本、活检和组织微阵列之间的一致性研究。
Clin Lung Cancer. 2019 Jul;20(4):258-262.e1. doi: 10.1016/j.cllc.2019.02.012. Epub 2019 Feb 27.
3
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers.PD-L1 表达和肿瘤突变负担是大多数癌症的独立生物标志物。
JCI Insight. 2019 Mar 21;4(6). doi: 10.1172/jci.insight.126908.
4
PD-L1 expression on routine samples of non-small cell lung cancer: results and critical issues from a 1-year experience of a centralised laboratory.常规非小细胞肺癌样本中的 PD-L1 表达：一个集中实验室 1 年经验的结果和关键问题。
J Clin Pathol. 2019 Jun;72(6):412-417. doi: 10.1136/jclinpath-2019-205732. Epub 2019 Mar 7.
5
Programmed death ligand 1 immunohistochemistry in non-small cell lung carcinoma.非小细胞肺癌中程序性死亡配体1免疫组织化学
J Thorac Dis. 2019 Jan;11(Suppl 1):S89-S101. doi: 10.21037/jtd.2018.12.103.
6
Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater.KEYNOTE-024 更新分析：PD-L1 肿瘤比例评分≥50%的晚期非小细胞肺癌的帕博利珠单抗对比铂类化疗
J Clin Oncol. 2019 Mar 1;37(7):537-546. doi: 10.1200/JCO.18.00149. Epub 2019 Jan 8.
7
Tumor mutational burden assessment as a predictive biomarker for immunotherapy in lung cancer patients: getting ready for prime-time or not?肿瘤突变负荷评估作为肺癌患者免疫治疗的预测生物标志物：是否已准备好进入黄金时代？
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8
PD-L1 Assays 22C3 and SP263 are Not Interchangeable in Non-Small Cell Lung Cancer When Considering Clinically Relevant Cutoffs: An Interclone Evaluation by Differently Trained Pathologists.PD-L1 检测试剂 22C3 和 SP263 在考虑临床相关截断值时在非小细胞肺癌中不可互换：不同培训的病理学家进行的克隆间评估。
Am J Surg Pathol. 2018 Oct;42(10):1384-1389. doi: 10.1097/PAS.0000000000001105.
9
Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer.帕博利珠单抗联合化疗治疗转移性非小细胞肺癌。
N Engl J Med. 2018 May 31;378(22):2078-2092. doi: 10.1056/NEJMoa1801005. Epub 2018 Apr 16.
10
Use of the 22C3 anti-programmed death-ligand 1 antibody to determine programmed death-ligand 1 expression in cytology samples obtained from non-small cell lung cancer patients.利用 22C3 抗程序性死亡配体 1 抗体检测非小细胞肺癌患者细胞学样本中的程序性死亡配体 1 表达。
Cancer Cytopathol. 2018 Apr;126(4):264-274. doi: 10.1002/cncy.21977. Epub 2018 Feb 7.

First-line immunotherapy for patients with advanced stage or metastatic non-small cell lung cancer…finally what threshold of PD-L1 expression on tumor cells?

作者信息

Hofman Paul

机构信息

Université Côte d'Azur, CHU Nice, FHU OncoAge, Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice, France.

Université Côte d'Azur, CNRS, INSERM, IRCAN, FHU OncoAge, Nice, France.

出版信息

Transl Lung Cancer Res. 2019 Oct;8(5):728-730. doi: 10.21037/tlcr.2019.04.18.

DOI:10.21037/tlcr.2019.04.18
PMID:31737511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6835100/
Abstract
摘要