Fat/Dachsous 家族钙黏蛋白在细胞和组织中的结构
Fat/Dachsous family cadherins in cell and tissue organisation.
机构信息
Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA.
Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA; Lunenfeld-Tanenbaum Research Institute, Sinai Health Systems, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
出版信息
Curr Opin Cell Biol. 2020 Feb;62:96-103. doi: 10.1016/j.ceb.2019.10.006. Epub 2019 Nov 15.
Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.
精确控制细胞和组织层面的组织对于建立和维持复杂生物体至关重要。非典型钙黏蛋白 Fat（Ft）、Fat2 和 Dachsous（Ds）通过调节生长和平面细胞极性来促进这种组织。本文描述了近年来对这些大型钙黏蛋白如何协调这些过程的理解的最新进展，并讨论了扩展其在微管、迁移和疾病调控中的功能的进一步进展。
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