Internal Medicine Department, Assistance Publique Hôpitaux de Marseille (AP-HM), Aix-Marseille University, Timone Hospital 264 Rue St Pierre, 13005 Marseille, France.
Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseille (AP-HM), Aix-Marseille University, Conception Hospital 147 Bd Baille, 13005 Marseille, France.
Clin Plast Surg. 2020 Jan;47(1):155-163. doi: 10.1016/j.cps.2019.08.016. Epub 2019 Oct 28.
Reparative, angiogenic, and immunomodulatory properties have been attributed to the cells in the adipose tissue-derived stromal vascular fraction. Because of these characteristics, in the last decade, fat grafting for treatment of autoimmune diseases has grown. This article focuses on systemic sclerosis, a rare autoimmune disease characterized by skin fibrosis and microvascular damage. Lesions of the face are almost always present; however, current therapy is insufficient and patients have considerable disability and social discomfort. This article presents our approach to using fat grafting in the face as an innovative and promising therapy for patients with systemic sclerosis.
脂肪组织来源的基质血管成分具有修复、血管生成和免疫调节特性。由于这些特性，过去十年中，脂肪移植治疗自身免疫性疾病的应用不断增加。本文重点介绍系统性硬化症，这是一种罕见的自身免疫性疾病，其特征是皮肤纤维化和微血管损伤。面部病变几乎总是存在，但目前的治疗方法不足，患者有相当大的残疾和社交不适。本文介绍了我们对面部脂肪移植的应用方法，作为一种治疗系统性硬化症患者的创新且有前途的疗法。
