Chan Megan Q, Balasubramanian Gokulakishnan
Department of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, 2nd floor, Columbus, OH, USA.
Curr Treat Options Gastroenterol. 2019 Dec;17(4):534-553. doi: 10.1007/s11938-019-00264-z.
With a globally aging population, dysphagia is a growing health concern among elderly. Increasing reflux disease has contributed to an increased prevalence of dysphagia from peptic strictures and esophageal cancer. Dysphagia can lead to malnutrition and aspiration pneumonia, causing considerable morbidity and mortality. This review article focuses on recent advances in the approach and management of esophageal dysphagia.
Endoscopic functional luminal imaging probe is a novel test that complements upper endoscopy, esophagram, and esophageal manometry for evaluation of esophageal dysphagia. Opioid induced esophageal dysfunction (OIED) is an emerging clinical entity that can mimic achalasia. Strictures refractory to dilation can be treated with intralesional steroid injections, electrosurgical incision, or esophageal stents. Peroral endoscopic myotomy (POEM) is gaining in popularity for treatment of achalasia and other spastic disorders of esophagus. Treatment of esophageal dysphagia may include proton pump inhibitors, endoscopic dilation, or surgery and requires a personalized approach based on risks and benefits. POEM is a valuable therapy for achalasia, but further studies are needed to evaluate its use, and other alternatives, for treatment of OIED and spastic esophageal disorders.
随着全球人口老龄化,吞咽困难在老年人中日益成为一个健康问题。反流性疾病的增加导致因消化性狭窄和食管癌引起的吞咽困难患病率上升。吞咽困难可导致营养不良和吸入性肺炎,造成相当高的发病率和死亡率。本文综述重点关注食管性吞咽困难的诊治进展。
内镜功能性管腔成像探头是一种新型检查方法,可补充上消化道内镜检查、食管造影和食管测压,用于评估食管性吞咽困难。阿片类药物所致食管功能障碍(OIED)是一种新出现的临床病症,可类似贲门失弛缓症。对扩张治疗无效的狭窄可采用病灶内注射类固醇、电外科切开或食管支架治疗。经口内镜下肌切开术(POEM)在治疗贲门失弛缓症和其他食管痉挛性疾病方面越来越受欢迎。食管性吞咽困难的治疗可能包括质子泵抑制剂、内镜扩张或手术,需要根据风险和获益采取个性化治疗方法。POEM是治疗贲门失弛缓症的一种有价值的疗法,但需要进一步研究以评估其用于治疗OIED和食管痉挛性疾病的效果及其他替代方法。