Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg, Russia 199004; email:
Guy Harvey Oceanographic Center, Halmos College of Natural Sciences and Oceanography, Nova Southeastern University, Fort Lauderdale, Florida 33004, USA.
Annu Rev Anim Biosci. 2020 Feb 15;8:1-24. doi: 10.1146/annurev-animal-021419-083944. Epub 2019 Nov 19.
This narrative is a personal view of adventures in genetic science and society that have blessed my life and career across five decades. The advances I enjoyed and the lessons I learned derive from educational training, substantial collaboration, and growing up in the genomics age. I parse the stories into six research disciplines my students, fellows, and colleagues have entered and, in some cases, made an important difference. The first is comparative genetics, where evolutionary inference is applied to genome organization, from building gene maps in the 1970s to building whole genome sequences today. The second area tracks the progression of molecular evolutionary advances and applications to resolve the hierarchical relationship among living species in the silence of prehistory. The third endeavor outlines the birth and maturation of genetic studies and application to species conservation. The fourth theme discusses how emerging viruses studied in a genomic sense opened our eyes to host-pathogen interaction and interdependence. The fifth research emphasis outlines the population genetic-based search and discovery of human restriction genes that influence the epidemiological outcome of abrupt outbreaks, notably HIV-AIDS and several cancers. Finally, the last arena explored illustrates how genetic individualization in human and animals has improved forensic evidence in capital crimes. Each discipline has intuitive and technological overlaps, and each has benefitted from the contribution of genetic and genomic principles I learned so long ago from The journey continues.
这篇叙述是我个人在遗传学科学和社会领域的冒险经历，这些经历丰富了我的生活和职业生涯，跨越了五十年。我所享受的进步和所学到的经验教训源于教育培训、大量的合作以及在基因组学时代的成长。我将这些故事分为六个研究领域，我的学生、研究员和同事们已经进入了这些领域，并在某些情况下产生了重要影响。第一个领域是比较遗传学，其中进化推断应用于基因组组织，从 20 世纪 70 年代构建基因图谱到今天构建全基因组序列。第二个领域跟踪分子进化进步的进展，并应用于解决史前沉默中现存物种的层次关系。第三个努力概述了遗传研究的诞生和成熟以及对物种保护的应用。第四个主题讨论了从基因组角度研究新兴病毒如何使我们了解宿主-病原体相互作用和相互依存关系。第五个研究重点概述了基于群体遗传学的搜索和发现影响突发疫情（特别是 HIV/AIDS 和几种癌症）流行病学结果的人类限制基因。最后，探索的最后一个领域说明了遗传个体化在人类和动物中的应用如何改善了死刑案件中的法医证据。每个学科都有直观和技术上的重叠，每个学科都受益于我很久以前从遗传学和基因组学原则中学到的贡献。旅程仍在继续。
