Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4792-4802. doi: 10.1167/iovs.18-26300.
The purpose of this study was to describe the normative values, distribution patterns, and correlated factors of macular ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), and outer retinal layer (ORL) thicknesses in Chinese children.
A sample of 3000 healthy children with different refractive status aged 6 to 19 years was consecutively examined. Demographics were recorded, and a comprehensive ophthalmic examination including refractive error and axial length (AL) was taken from all participants. The GCIPL, GCC, and ORL thicknesses were measured using swept source-optical coherence tomography (OCT), and multiple linear regression was used to determine which factors were associated with the thickness of each layer.
The average thickness was 77.00 ± 4.78 μm (95% confidence interval [CI]: 69.56-84.56 μm) in the GCIPL, 107.68 ± 5.95 μm (95% CI: 98.45-117.21 μm) in the GCC, and 178.57 ± 9.02 μm (95% CI: 164.33-192.56 μm) in the ORL. Multiple regression analysis indicated that GCIPL thickness was associated with sex (β = 0.168, P < 0.001), age (β = 0.126, P < 0.001), axial length (β = -0.181, P < 0.001), and refractive error (β = 0.233, P < 0.001). Age (β = 0.154, P < 0.001), sex (β = 0.102, P < 0.001), and refractive error (β = 0.149, P < 0.001) were associated independently with GCC thickness after adjusting for the other factors. Furthermore, age (β = 0.100, P < 0.001), sex (β = 0.163, P < 0.001), AL (β = -0.283, P < 0.001), and refractive error (β = 0.207, P < 0.001) were the independent factors associated with ORL thickness.
The present study established a normative pediatric database for macular layer thicknesses in healthy Chinese children, advancing the ability of OCT in diseases diagnosis and monitoring among children.
本研究旨在描述中国儿童黄斑神经节细胞-内丛状层（GCIPL）、神经节细胞复合体（GCC）和外层视网膜（ORL）厚度的正常值、分布模式和相关因素。
连续检查了 3000 名年龄在 6 至 19 岁之间、屈光状态不同的健康儿童。记录了他们的人口统计学资料，并对所有参与者进行了全面的眼科检查，包括屈光不正和眼轴（AL）。使用扫频源光学相干断层扫描（OCT）测量 GCIPL、GCC 和 ORL 厚度，采用多元线性回归确定与各层厚度相关的因素。
GCIPL 的平均厚度为 77.00±4.78μm（95%置信区间[CI]：69.56-84.56μm），GCC 为 107.68±5.95μm（95%CI：98.45-117.21μm），ORL 为 178.57±9.02μm（95%CI：164.33-192.56μm）。多元回归分析表明，GCIPL 厚度与性别（β=0.168，P<0.001）、年龄（β=0.126，P<0.001）、眼轴（β=-0.181，P<0.001）和屈光不正（β=0.233，P<0.001）有关。年龄（β=0.154，P<0.001）、性别（β=0.102，P<0.001）和屈光不正（β=0.149，P<0.001）是在调整其他因素后与 GCC 厚度独立相关的因素。此外，年龄（β=0.100，P<0.001）、性别（β=0.163，P<0.001）、AL（β=-0.283，P<0.001）和屈光不正（β=0.207，P<0.001）是与 ORL 厚度相关的独立因素。
本研究建立了中国健康儿童黄斑层厚度的正常儿科数据库，提高了 OCT 在儿童疾病诊断和监测中的能力。
