Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Molecules. 2019 Nov 16;24(22):4161. doi: 10.3390/molecules24224161.
Pyrido[2,3-]pyrimidines () are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-]pyrimidine-7(8)-ones () due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure have increased almost exponentially in the last 10 years. The present review covers the synthetic methods used for the synthesis of pyrido[2,3-]pyrimidine-7(8)-ones (), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds.
吡啶并[2,3-]嘧啶类化合物（）是一类具有特权杂环结构的化合物，能够为体内的多个受体提供配体。在这些结构中，我们的团队和其他团队对吡啶并[2,3-]嘧啶-7(8)-酮类化合物（）特别感兴趣，因为它们与 DNA 和 RNA 中存在的氮碱基相似。目前已经描述了超过 20,000 种结构，对应约 2900 个参考文献（其中一半是专利）。此外，在过去 10 年中，包含一般结构化合物的参考文献数量几乎呈指数级增长。本综述涵盖了用于合成吡啶并[2,3-]嘧啶-7(8)-酮类化合物（）的合成方法，既可以从预先形成的嘧啶环或吡啶环开始，也可以从预先形成的嘧啶环或吡啶环开始，还涵盖了此类化合物的生物医学应用。
